1. Epigenetics
  2. Histone Demethylase
  3. CPI-455 hydrochloride

CPI-455 hydrochloride 是一种特异性的泛 KDM5 抑制剂,对 KDM5A 的 IC50 为 10 nM,CPI-455 hydrochloride 介导 KDM5 抑制,提高 H3K4me3 的整体水平,并减少多肿瘤细胞系模型中耐药的持久癌细胞的数量。

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CPI-455 hydrochloride Chemical Structure

CPI-455 hydrochloride Chemical Structure

CAS No. : 2095432-28-1

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CPI-455 hydrochloride 的其他形式现货产品:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CPI-455 hydrochloride is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 hydrochloride mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1].

IC50 & Target

KDM5

 

体外研究
(In Vitro)

CPI-455 hydrochloride 介导 KDM5 抑制,提高 H3K4 三甲基化 (H3K4me3) 的总体水平,并减少使用标准化疗或靶向药物处理的多种癌细胞系模型中的 DTP 数量[1]
CPI-455 盐酸盐,对目标 KDM5 蛋白具有高亲和力。在 24 小时内,在暴露于两种活性化合物 CPI-455 和 CPI-766 中的任何一种后,观察到 H3K4me3 以剂量依赖性方式增加。 KDM5 Inhibitor CPI0455 在 3 种管腔乳腺癌细胞系 MCF-7、T-47 和 EFM-19 中的 IC50 计算值分别为 35.4、26.19 和 16.13 μM[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

在小鼠体内双重阻断 B7-H4 和 KDM5B(CPI-455 hydrochloride,50/70 mg/kg,腹腔注射,每日)可引发保护性免疫[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

314.77

Formula

C16H15ClN4O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
CPI-455 hydrochloride
目录号:
HY-100421A
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