2. Gene
  3. RENBP - renin binding protein Gene

RENBP - renin binding protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肾素结合蛋白

种属: Homo sapiens

同用名: RBP; RNBP

基因 ID: 5973 | 基因类型: protein coding

关于 RENBP

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,935,269-153,944,643 (from NCBI)

This gene has 10 transcripts (splice variants) and 175 orthologues. Broad expression in kidney (RPKM 29.7), spleen (RPKM 23.5) and 18 other tissues.

功能概要

该基因产物通过与肾素形成二聚体来抑制肾素活性，肾素是一种称为高分子量肾素的复合物。编码的蛋白质包含一个亮氨酸拉链结构域，这对于它与肾素的二聚化是必不可少的。该基因产物可催化 N-乙酰氨基葡萄糖相互转化为 N-乙酰甘露糖胺，表明它是一种 GlcNAc 2-差向异构酶。文献中已经描述了利用替代启动子的转录变体。[RefSeq 提供，2008 年 7 月]

The gene product inhibits Renin activity by forming a dimer with Renin, a complex known as high molecular weight Renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with Renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]

RENBP 基因产物(1)

mRNA Protein Name
NM_002910.6 NP_002901.2 N-acylglucosamine 2-epimerase
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N-acylglucosamine 2-epimerase activity IDA
IDA: 通过直接分析推断
9990133 GOA
enables N-acylglucosamine 2-epimerase activity IMP
IMP: 通过突变表型推断
10502668 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
9990133 GOA
enables peptidase inhibitor activity IDA
IDA: 通过直接分析推断
9990133 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RENBP 蛋白结构

GlcNAc_2-epim

GlcNAc_2-epim: N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) (47 - 386)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 427 a.a.
蛋白主名 其他名称

N-acylglucosamine 2-epimerase

AGE

RENBP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RENBP P51606 SCML1 Homo sapiens Q9UN30-2
Y2H Prey Pooling
32296183
种属内
RENBP P51606 SCML1 Homo sapiens Q9UN30-2
Validated Y2H
32296183
种属内
RENBP P51606 SCML1 Homo sapiens Q9UN30-2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nemaline Myopathy 1

Cap Myopathy 1

NEM1

Nemaline Myopathy 1, Autosomal Dominant Or Recessive

Nemaline Myopathy, Type 1

CAPM1

Cap Disease

Cap Myopathy Tpm3-Related

Nemaline Myopathy 1 Autosomal Dominant Or Recessive

Myopathy, Nemaline, Type 1

Cap Myopathy
Colorblindness, Partial, Protan Series

Protanopia

Red Color Blindness

Protan Defect

CBP

Red Colorblindness

Colorblindness, Protan

Color Blindness, Red
Red-Green Color Blindness

Deutan Defect

Deuteranopia

Reduced Red-Green Discrimination

Color Blindness, Red-Green

Colorblindness, Partial, Deutan Series
Sialuria

Sialuria, French Type

French Type Sialuria

Sialuria French Type

Sialic Acid Storage Disease

Sialic Acid Storage Disease, Finnish Type

Infantile Sialic Acid Storage Disease
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
Glutaric Acidemia I

Glutaryl-Coa Dehydrogenase Deficiency

GA1

Glutaric Acidemia Type 1

Glutaric Aciduria 1

Glutaric Aciduria Type 1

Glutaric Acidemia Type I

Glutaric Aciduria, Type 1

Glutaric Aciduria I

Ga I

Glutaricaciduria, Type I

Glutaryl-Coenzyme A Dehydrogenase Deficiency

Glutaric Academia Type 1

Glutaric Aciduria Type I

Ga-1

Gcdh Deficiency

Ga 1

Glutaric Acidemia 1

Gcdhd

Glutaric Aciduria, Type I

Glutaricaciduria I

Ga-I

Glutaricaciduria, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11842 RENBP Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RENBP RGD RGD:621688
Bos taurus RENBP VGNC VGNC:33866
Macaca mulatta RENBP VGNC VGNC:76895
Mus musculus RENBP MGD MGI:105940
Canis familiaris RENBP VGNC VGNC:54185
Felis catus RENBP VGNC VGNC:69287
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