2. Gene
  3. Cttn - cortactin Gene

Cttn - cortactin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Cttnb

基因 ID: 60465 | 基因类型: protein coding

关于 Cttn

功能概要

Enables Arp2/3 complex binding activity and proline-rich region binding activity. Involved in several processes, including focal adhesion assembly; modification of postsynaptic actin cytoskeleton; and plasma membrane bounded cell projection organization. Located in cell junction and clathrin-coated pit. Is active in glutamatergic synapse and postsynaptic actin Cytoskeleton. Colocalizes with actin filament; focal adhesion; and growth cone. Orthologous to human CTTN (cortactin). [provided by Alliance of Genome Resources, Apr 2022]

Cttn 基因产物(3)

mRNA Protein Name
NM_001398643.1 NP_001385572.1 src substrate cortactin isoform 1
NM_001398644.1 NP_001385573.1 src substrate cortactin isoform 3
NM_021868.3 NP_068640.2 src substrate cortactin isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Arp2/3 complex binding IPI
IPI: 通过物理相互作用推断
18775315 RGD
enables proline-rich region binding IPI
IPI: 通过物理相互作用推断
9813110 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15159385 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
18768925 RGD
involved in cell motility IMP
IMP: 通过突变表型推断
18768925 RGD
involved in focal adhesion assembly IMP
IMP: 通过突变表型推断
18768925 RGD
involved in lamellipodium organization IMP
IMP: 通过突变表型推断
18768925 RGD
involved in modification of postsynaptic actin cytoskeleton IDA
IDA: 通过直接分析推断
14684878 RGD
involved in modification of postsynaptic actin cytoskeleton IMP
IMP: 通过突变表型推断
14684878 RGD
involved in modification of postsynaptic structure IDA
IDA: 通过直接分析推断
14684878 RGD
involved in modification of postsynaptic structure IMP
IMP: 通过突变表型推断
14684878 RGD
involved in neuron projection morphogenesis IMP
IMP: 通过突变表型推断
21210813 RGD
involved in positive regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
18768925 RGD
involved in positive regulation of chemotaxis IMP
IMP: 通过突变表型推断
19373774 RGD
involved in receptor-mediated endocytosis IDA
IDA: 通过直接分析推断
12612086 RGD
involved in receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
19995918 RGD
involved in regulation of axon extension IMP
IMP: 通过突变表型推断
21210813 RGD
involved in regulation of cell projection assembly IMP
IMP: 通过突变表型推断
19373774 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin filament IMP
IMP: 通过突变表型推断
18768925 RGD
located in cell junction IDA
IDA: 通过直接分析推断
21210813 RGD
located in clathrin-coated pit IDA
IDA: 通过直接分析推断
19995918 RGD
located in focal adhesion IMP
IMP: 通过突变表型推断
18768925 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
14684878 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
14684878 RGD
located in growth cone IDA
IDA: 通过直接分析推断
21210813 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
15548644 RGD
is active in postsynaptic actin cytoskeleton IDA
IDA: 通过直接分析推断
15548644 RGD
part of voltage-gated potassium channel complex IDA
IDA: 通过直接分析推断
12151401 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

src substrate cortactin

Cttn 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Cttn Q66HL2 Cfl1 Rattus norvegicus P45592
Anti Bait CoIP
19704022
种属内
Cttn Q66HL2 Cfl1 Rattus norvegicus P45592
FRET
19704022
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03350 CTTN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22133 Cttn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28655 Cttn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cttn NCBI NCBI:2017
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