2. Gene
  3. Cfl1 - cofilin 1 Gene

Cfl1 - cofilin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29271 | 基因类型: protein coding

关于 Cfl1

功能概要

Enables actin filament binding activity; phosphatidylinositol bisphosphate binding activity; and protein Phosphatase binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cellular component organization; and positive regulation of cellular component organization. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in several cellular components, including cofilin-actin rod; growth cone; and lamellipodium. Is active in glutamatergic synapse. Used to study myocardial infarction. Biomarker of several diseases, including epilepsy (multiple); impotence; muscular atrophy; ureteral obstruction; and vitamin B12 deficiency. Orthologous to human CFL1 (cofilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cfl1 基因产物(2)

mRNA Protein Name
NM_017147.3 NP_058843.1 cofilin-1
NM_017147.3 NP_058843.1 cofilin-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IMP
IMP: 通过突变表型推断
12566455 RGD
enables actin filament binding IDA
IDA: 通过直接分析推断
24740405 RGD
enables phosphatidylinositol bisphosphate binding IPI
IPI: 通过物理相互作用推断
19029335 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
19704022 RGD
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
26324884 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell projection organization IDA
IDA: 通过直接分析推断
16286931 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: 通过表达模式推断
26324884 RGD
involved in cellular response to epidermal growth factor stimulus IMP
IMP: 通过突变表型推断
23704350 RGD
involved in cellular response to ether IEP
IEP: 通过表达模式推断
24239914 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: 通过直接分析推断
23765104 RGD
involved in cellular response to insulin-like growth factor stimulus IDA
IDA: 通过直接分析推断
24195677 RGD
involved in cellular response to interleukin-1 IDA
IDA: 通过直接分析推断
24760020 RGD
involved in cellular response to interleukin-6 IDA
IDA: 通过直接分析推断
24760020 RGD
involved in cellular response to tumor necrosis factor IDA
IDA: 通过直接分析推断
24760020 RGD
involved in hippocampus development IEP
IEP: 通过表达模式推断
27073215 RGD
involved in modification of postsynaptic actin cytoskeleton EXP
EXP: 通过实验结果推断
16025109 RGD
involved in modification of postsynaptic actin cytoskeleton IDA
IDA: 通过直接分析推断
16025109 RGD
involved in modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
16025109 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
16025109 RGD
involved in negative regulation of actin filament bundle assembly IMP
IMP: 通过突变表型推断
24093776 RGD
involved in negative regulation of actin filament depolymerization IMP
IMP: 通过突变表型推断
15252126 RGD
involved in negative regulation of cell adhesion IMP
IMP: 通过突变表型推断
26169356 RGD
involved in negative regulation of cell motility IMP
IMP: 通过突变表型推断
24093776 RGD
acts upstream of or within negative regulation of cell size IDA
IDA: 通过直接分析推断
16286931 RGD
involved in negative regulation of dendritic spine maintenance IMP
IMP: 通过突变表型推断
23974706 RGD
involved in negative regulation of lamellipodium assembly IMP
IMP: 通过突变表型推断
24093776 RGD
involved in negative regulation of postsynaptic density organization IMP
IMP: 通过突变表型推断
26169356 RGD
involved in negative regulation of unidimensional cell growth IMP
IMP: 通过突变表型推断
24093776 RGD
involved in positive regulation of NMDA glutamate receptor activity IMP
IMP: 通过突变表型推断
24089484 RGD
involved in positive regulation of barbed-end actin filament capping IMP
IMP: 通过突变表型推断
23704350 RGD
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
24093776 RGD
involved in positive regulation of cell motility IMP
IMP: 通过突变表型推断
24214978 RGD
involved in positive regulation of dendritic spine development IMP
IMP: 通过突变表型推断
25723479 RGD
involved in positive regulation of establishment of cell polarity regulating cell shape IMP
IMP: 通过突变表型推断
26169356 RGD
involved in positive regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
24093776 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: 通过突变表型推断
15252126 RGD
involved in positive regulation of protein localization to cell leading edge IMP
IMP: 通过突变表型推断
26324884 RGD
involved in positive regulation of proteolysis IMP
IMP: 通过突变表型推断
24093776 RGD
involved in positive regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
25723479 RGD
involved in protein import into nucleus IMP
IMP: 通过突变表型推断
12566455 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
26678157 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
26678157 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell leading edge IDA
IDA: 通过直接分析推断
15252126 RGD
located in cofilin-actin rod IDA
IDA: 通过直接分析推断
24760020 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
24760020 RGD
located in filopodium IDA
IDA: 通过直接分析推断
24515839 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
16025109 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16025109 RGD
located in growth cone IDA
IDA: 通过直接分析推断
24515839 RGD
located in lamellipodium IDA
IDA: 通过直接分析推断
15252126 RGD
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
27642592 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
24515839 RGD
located in synaptic membrane IDA
IDA: 通过直接分析推断
25708984 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cofilin-1

cofilin 1, non-muscle

Cfl1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Cfl1 P45592 Cttn Rattus norvegicus Q66HL2
Anti Bait CoIP
19704022
种属内
Cfl1 P45592 Cttn Rattus norvegicus Q66HL2
Anti Tag CoIP
19704022
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15700 VPS72 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS02568 CFL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18607 Cfl1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25093 Cfl1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cfl1 NCBI NCBI:1072
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