LPIN3 - lipin 3 Gene

中文名称：立平 3

种属: Homo sapiens

同用名: SMP2; LIPN3L; dJ620E11.2

关于 LPIN3

功能概要

该基因编码的蛋白质是 lipin 蛋白质家族的成员，所有家族成员在其 C 末端区域都具有很强的同源性。这种蛋白质被认为与其他 lipin 家族成员形成异源寡聚体，而一个家族成员 lipin 1 也可以形成同源寡聚体。该蛋白质包含磷脂磷酸酶 1 (PAP1) 活性的保守基序以及与转录共激活因子相互作用的结构域。脂蛋白复合物在细胞质中起作用以催化磷脂酸的去磷酸化以产生二酰基甘油，其是甘油三酯和磷脂的前体。脂蛋白复合物也被认为作为细胞核中的转录共激活因子调节基因表达。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 9 月]

The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with Other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate Phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and Phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]