2. Gene
  3. SQLE - squalene epoxidase Gene

SQLE - squalene epoxidase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：角鲨烯环氧酶

种属: Homo sapiens

基因 ID: 6713 | 基因类型: protein coding

关于 SQLE

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:124,998,505-125,022,283 (from NCBI)

This gene has 6 transcripts (splice variants) and 213 orthologues. Broad expression in testis (RPKM 28.6), esophagus (RPKM 19.3) and 22 other tissues.

功能概要

角鲨烯环氧酶催化甾醇生物合成的第一个氧化步骤，被认为是该途径中的限速酶之一。[RefSeq 提供，2008 年 7 月]

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting Enzymes in this pathway. [provided by RefSeq, Jul 2008]

SQLE 基因产物(1)

mRNA Protein Name
NM_003129.4 NP_003120.2 squalene monooxygenase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables FAD binding IDA
IDA: 通过直接分析推断
30626872 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
29765154 GOA
enables squalene monooxygenase activity IDA
IDA: 通过直接分析推断
30626872 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lipid droplet formation IMP
IMP: 通过突变表型推断
29765154 GOA
involved in regulation of cell population proliferation IMP
IMP: 通过突变表型推断
29765154 GOA
involved in sterol biosynthetic process IDA
IDA: 通过直接分析推断
30626872 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in intracellular membrane-bounded organelle IDA
IDA: 通过直接分析推断
30626872 GOA
located in membrane IDA
IDA: 通过直接分析推断
30626872 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SQLE 蛋白结构

Pyr_redox

Pyr_redox: Pyridine nucleotide-disulphide oxidoreductase (126 - 154)

SE

SE: Squalene epoxidase (277 - 548)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 574 a.a.
蛋白主名 其他名称

squalene monooxygenase

SE

SQLE 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SQLE Q14534 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
种属内
SQLE Q14534 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
种属内
SQLE Q14534 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
种属内
SQLE Q14534 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
种属内
SQLE Q14534 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
种属内
SQLE Q14534 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
种属内
SQLE Q14534 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
种属内
SQLE Q14534 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
种属内
SQLE Q14534 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tinea Corporis

Dermatophytosis Of The Body

Dermatophytosis Of The Trunk
Tinea Cruris

Dermatophytosis Of Groin & Perianal Area

Dermatophytosis Of Groin And Perianal Area

Dhobie Itch

Tinea Of Perianal Region
Tinea Pedis

Athlete'S Foot

Dermatophytosis Of Foot

Ringworm Of Foot

Moccasin Foot
Tinea Unguium

Dermatophytosis Of Nail

Onychomycosis Due To Dermatophyte

Cellulitis And Abscess

Cellulitis And Abscess Of Buttock

Cellulitis And Abscess Of Face

Cellulitis And Abscess Of Finger

Cellulitis And Abscess Of Finger And Toe

Cellulitis And Abscess Of Gluteal Region

Cellulitis And Abscess Of Trunk

Cellulitis And Abscess Of Upper Arm And Forearm

Dermatophytic Onychia

Dermatophytic Onychomycosis

Onychomycosis

Ringworm Of Nails

Tinea Of Nail
Tinea Capitis

Dermatophytosis Of Scalp

Scalp Ringworm

Dermatophytosis Of Scalp Or Beard

Tinea Capitis Due To Trichophyton Rubrum

Trichophyton Rubrum Tinea Capitis
Tinea Manuum

Tinea Manus

Dermatophytosis Of Hand
Dermatophytosis

Tinea

Dermatophytosis, Unspecified

Ringworm

Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

Cutaneous Mycosis

Dermal Mycosis

Superficial Mycosis, Unspecified

Fungus Infection Of Skin

Skin Mycosis

Dermatitis Fungoid

Fungal Dermatitis

Fungal Dermatosis

Mycotic Infection Of Skin
Candida Glabrata

Torulopsis Glabrata
Tinea Barbae

Dermatophytosis Of Beard
Humeroradial Synostosis

Humero-Radial Fusion

Humero-Radial Synostosis

Ramer Ladda Syndrome
Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection
Antley-Bixler Syndrome

Trapezoidocephaly Synostosis Syndrome

Trapezoidocephaly-Synostosis Syndrome

Antley Bixler Syndrome

Multisynostotic Osteodysgenesis With Long Bone Fractures

Osteodysgenesis, Multisynostotic With Fractures

Antley-Bixler Syndrome, Autosomal Dominant

Antley-Bixler Syndrome Phenotype
Smith-Lemli-Opitz Syndrome

SLOS

Rsh Syndrome

7-Dehydrocholesterol Reductase Deficiency

Slo Syndrome

Rutledge Lethal Multiple Congenital Anomaly Syndrome

Lethal Acrodysgenital Syndrome

Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung

Smith-Opitz-Inborn Syndrome

Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung

Smith Lemli Opitz Syndrome

Smith-Lemli-Opitz Syndrome, Type Ii
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-160093 SQLE-IN-1 98.15% 否
HY-RS13743 SQLE Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17967 Sqle Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24438 Sqle Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SQLE VGNC VGNC:77875
Felis catus SQLE VGNC VGNC:65668
Rattus norvegicus SQLE RGD RGD:3755
Mus musculus SQLE MGD MGI:109296
Canis familiaris SQLE VGNC VGNC:46786
Bos taurus SQLE VGNC VGNC:35264
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z