TBXAS1 - thromboxane A synthase 1 Gene

中文名称：血栓素 A 合酶 1

种属: Homo sapiens

同用名: TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14

关于 TBXAS1

功能概要

该基因编码细胞色素 P450 酶超家族的成员。细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。然而，根据序列相似性而非功能相似性，该蛋白质被认为是细胞色素 P450 超家族的成员。这种内质网膜蛋白催化前列腺素 H2 转化为凝血恶烷 A2，凝血恶烷 A2 是一种有效的血管收缩剂和血小板聚集诱导剂。该酶在多种病理生理过程中发挥作用，包括止血、心血管疾病和中风。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 8 月]

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. However, this protein is considered a member of the Cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, Cardiovascular Disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]