TOP2B - DNA topoisomerase II beta Gene

中文名称：DNA 拓扑异构酶 II β

种属: Homo sapiens

同用名: BILU; TOPIIB; top2beta

关于 TOP2B

功能概要

该基因编码一种 DNA 拓扑异构酶，一种在转录过程中控制和改变 DNA 拓扑状态的酶。这种核酶参与染色体浓缩、染色单体分离以及 DNA 转录和复制过程中发生的扭转应力的缓解等过程。它催化双链 DNA 的两条链的瞬时断裂和重新连接，使链彼此穿过，从而改变 DNA 的拓扑结构。这种酶的两种形式可能是基因复制事件的产物。编码这种形式的基因，β，位于 3 号染色体，而 alpha 形式位于 17 号染色体。编码这种酶的基因作为几种抗癌剂的靶标，并且该基因的各种突变与发展有关的耐药性。这种酶的活性降低也可能在共济失调-毛细血管扩张中起作用。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 8 月]

This gene encodes a DNA Topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several Anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]