2. Gene
  3. TST - thiosulfate sulfurtransferase Gene

TST - thiosulfate sulfurtransferase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：硫代硫酸盐硫转移酶

种属: Homo sapiens

同用名: RDS

基因 ID: 7263 | 基因类型: protein coding

关于 TST

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:37,010,859-37,020,183 (from NCBI)

This gene has 4 transcripts (splice variants), 295 orthologues and 1 paralogue. Broad expression in colon (RPKM 83.2), liver (RPKM 73.2) and 22 other tissues.

功能概要

这是编码相似蛋白质的两个相邻基因之一，每个基因都包含两个硫氰酸酶结构域。编码的蛋白质定位于线粒体并催化硫代硫酸盐和氰化物转化为硫氰酸盐和亚硫酸盐。此外，该蛋白质与 5S 核糖体 RNA 相互作用并促进其进入线粒体。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 7 月]

This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

TST 基因产物(2)

mRNA Protein Name
NM_001270483.1 NP_001257412.1 thiosulfate sulfurtransferase
NM_003312.6 NP_003303.2 thiosulfate sulfurtransferase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 5S rRNA binding IDA
IDA: 通过直接分析推断
20663881 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in epithelial cell differentiation IDA
IDA: 通过直接分析推断
21492153 GOA
involved in rRNA import into mitochondrion IMP
IMP: 通过突变表型推断
20663881 GOA
involved in rRNA transport IDA
IDA: 通过直接分析推断
21685364 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TST 蛋白结构

Rhodanese

Rhodanese: Rhodanese-like domain (14 - 136)

Rhodanese

Rhodanese: Rhodanese-like domain (165 - 280)

  • 0
  • 100
  • 200
  • 297 a.a.
蛋白主名 其他名称

thiosulfate sulfurtransferase

epididymis secretory sperm binding protein

关联疾病

疾病名称 别名
Commensal Bacterial Infectious Disease
Staphyloenterotoxemia

Staphylococcal Food Poisoning

Staphylococcal Toxaemia Due To Food

Staphyloenterotoxicosis
Ritter'S Disease

Staphylococcal Scalded Skin Syndrome

Pemphigus Neonatorum

Ritter Disease

Dermatitis Exfoliativa Neonatorum

Scalded Skin Syndrome

Toxic Epidermal Necrolysis, Subcorneal Type

Generalized Exfoliative Disease

Ssss

Ssss - [Staphylococcal Scalded Skin Syndrome]
Encephalopathy, Ethylmalonic

Ethylmalonic Encephalopathy

EE

Epema Syndrome

Encephalopathy, Petechiae, And Ethylmalonic Aciduria

Ethe1 Deficiency

Eme

Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Pyomyositis

Tropical Pyomyositis

Myositis Tropicans

Myositis Purulenta Tropica

Pm

Suppurative Myositis

Purulent Myositis
Endocardium Disease
Scarlet Fever

Scarlatina

Scarlatina Nos
Carbuncle

Carbuncle And Furuncle Of Any Part Of Face Except Eye

Carbuncle And Furuncle Of Buttock

Carbuncle And Furuncle Of Face

Carbuncle And Furuncle Of Foot

Carbuncle And Furuncle Of Gluteal Region

Carbuncle And Furuncle Of Hand

Carbuncle And Furuncle Of Leg Except Foot

Carbuncle And Furuncle Of Neck

Carbuncle And Furuncle Of Trunk

Carbuncle And Furuncle Of Upper Arm And Forearm
Infective Endocarditis

Bacterial Endocarditis

Endocarditis, Infective

Infectious Endocarditis

Endocarditis Infective
Discitis
Necrotizing Fasciitis

Fasciitis, Necrotizing
Impetigo
Septic Arthritis

Infectious Arthritis

Arthritis, Infectious

Arthritis Septic

Arthritis, Bacterial
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B1395 Mecamylamine hydrochloride ≥98.0% 是
HY-B1395A Mecamylamine ≥90.0% 否
Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P9991 Osemitamab Inhibitor 99.43% Phase 2
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W105505 SAMe-1,4-Butanedisulfonate 98.03% 否
HY-147735 GABAA receptor agonist 1 Agonist / 否
HY-147736 GABAA receptor agonist 2 Agonist / 否
HY-162775 TST1N-224 Inhibitor / 否
HY-RS15190 TST Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS15191 TSTD1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17363 Tst Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23817 Tst Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W143822 6-(Tritylthio)hexanoic acid / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TST VGNC VGNC:36449
Mus musculus TST MGD MGI:98852
Felis catus TST VGNC VGNC:66647
Canis familiaris TST VGNC VGNC:47932
Rattus norvegicus TST RGD RGD:3913
Macaca mulatta TST VGNC VGNC:78664
Others TST NCBI
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