UBE2D2 - ubiquitin conjugating enzyme E2 D2 Gene

中文名称：泛素结合酶 E2 D2

种属: Homo sapiens

同用名: UBC4; PUBC1; UBCH4; UBC4/5; UBCH5B; E2(17)KB2

基因 ID: 7322 | 基因类型: protein coding

关于 UBE2D2

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,526,240-139,628,434 (from NCBI)

This gene has 10 transcripts (splice variants), 140 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 32.5), brain (RPKM 24.1) and 25 other tissues.

功能概要

真核生物中错误折叠、受损或短寿命蛋白质的调节降解是通过泛素 (Ub) -蛋白酶体系统 (UPS) 发生的。 UPS 系统的一个组成部分是目标蛋白的泛素化和含 Ub 蛋白的共价连接形成聚合链，将它们标记为 26S 蛋白酶体介导的降解的目标。蛋白质的泛素化由一系列酶介导，包括 E1 (泛素激活) 、E2 (泛素结合) 和 E3 (泛素连接酶) 酶。该基因编码 E2 酶家族的一个成员。这种酶的底物包括肿瘤抑制蛋白 p53 和过氧化物酶体生物发生因子 5 (PEX5) 。可变剪接导致该基因的多个转录变体。[RefSeq 提供，2013 年 5 月]

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of Enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) Enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

UBE2D2 基因产物(2)

mRNA	Protein	Name
NM_003339.3	NP_003330.1	ubiquitin-conjugating enzyme E2 D2 isoform 1
NM_181838.2	NP_862821.1	ubiquitin-conjugating enzyme E2 D2 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14667819	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: 通过直接分析推断	14593114	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	8530467	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	18359941	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein K48-linked ubiquitination	IDA IDA: 通过直接分析推断	20061386	GOA
involved in protein autoubiquitination	IDA IDA: 通过直接分析推断	21068390	GOA
involved in protein polyubiquitination	IDA IDA: 通过直接分析推断	15247280	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	9990509	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of protein-containing complex	IDA IDA: 通过直接分析推断	22797923	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBE2D2 蛋白结构

UQ_con

0
100
147 a.a.

蛋白主名

其他名称

ubiquitin-conjugating enzyme E2 D2

(E3-independent) E2 ubiquitin-conjugating enzyme D2

UBE2D2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UBE2D2	P62837	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
种属内	UBE2D2	P62837	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
种属内	UBE2D2	P62837	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	OTUB1	Homo sapiens	Q96FW1	Anti Tag CoIP	22124327
种属内	UBE2D2	P62837	OTUB1	Homo sapiens	Q96FW1	Anti Tag CoIP	33961781
种属内	UBE2D2	P62837	OTUB1	Homo sapiens	Q96FW1	Anti Tag CoIP	28514442
种属内	UBE2D2	P62837	OTUB1	Homo sapiens	Q96FW1	Validated Y2H	32296183
种属内	UBE2D2	P62837	OTUB1	Homo sapiens	Q96FW1	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	OTUB1	Homo sapiens	Q96FW1	Y2H Array	32296183
种属内	UBE2D2	P62837	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
种属内	UBE2D2	P62837	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
种属内	UBE2D2	P62837	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	CHFR	Homo sapiens	Q96EP1-2	Y2H Array	32296183
种属内	UBE2D2	P62837	CHFR	Homo sapiens	Q96EP1-2	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	CHFR	Homo sapiens	Q96EP1-2	Validated Y2H	32296183
种属内	UBE2D2	P62837	RNF43	Homo sapiens	Q68DV7	Y2H Array	19690564
种属内	UBE2D2	P62837	RNF25	Homo sapiens	Q96BH1	Anti Tag CoIP	33961781
种属内	UBE2D2	P62837	RNF25	Homo sapiens	Q96BH1	Anti Tag CoIP	28514442
种属内	UBE2D2	P62837	RNF25	Homo sapiens	Q96BH1	Y2H Array	19549727
种属内	UBE2D2	P62837	RNF115	Homo sapiens	Q9Y4L5	Validated Y2H	32296183
种属内	UBE2D2	P62837	RNF115	Homo sapiens	Q9Y4L5	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	RNF115	Homo sapiens	Q9Y4L5	Y2H Array	32296183
种属内	UBE2D2	P62837	ZNRF1	Homo sapiens	Q8ND25	Y2H Array	19549727
种属内	UBE2D2	P62837	ZNRF1	Homo sapiens	Q8ND25	Enzymatic Study	19549727
种属内	UBE2D2	P62837	ZNRF1	Homo sapiens	Q8ND25	Validated Y2H	32296183
种属内	UBE2D2	P62837	ZNRF1	Homo sapiens	Q8ND25	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	ZNRF1	Homo sapiens	Q8ND25	Y2H Array	32296183
种属内	UBE2D2	P62837	ZNRF1	Homo sapiens	Q8ND25	Y2H	19549727
种属内	UBE2D2	P62837	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
种属内	UBE2D2	P62837	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
种属内	UBE2D2	P62837	RNF185	Homo sapiens	Q96GF1	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	RNF185	Homo sapiens	Q96GF1	Y2H Array	32296183
种属内	UBE2D2	P62837	RNF185	Homo sapiens	Q96GF1	Validated Y2H	32296183
种属内	UBE2D2	P62837	MID1	Homo sapiens	O15344	Y2H Array	32296183
种属内	UBE2D2	P62837	MID1	Homo sapiens	O15344	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	32296183
种属内	UBE2D2	P62837	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
种属内	UBE2D2	P62837	RNF5	Homo sapiens	Q99942	Y2H Array	19549727
种属内	UBE2D2	P62837	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	RNF5	Homo sapiens	Q99942	Y2H	19549727
种属内	UBE2D2	P62837	RNF5	Homo sapiens	Q99942	Pull Down	20152160
种属内	UBE2D2	P62837	RNF5	Homo sapiens	Q99942	Validated Y2H	32296183
种属内	UBE2D2	P62837	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
种属内	UBE2D2	P62837	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	19549727
种属内	UBE2D2	P62837	TRAF6	Homo sapiens	Q9Y4K3	Validated Y2H	32296183
种属内	UBE2D2	P62837	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	32296183
种属内	UBE2D2	P62837	TRAF6	Homo sapiens	Q9Y4K3	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	RNF8	Homo sapiens	O76064	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	RNF8	Homo sapiens	O76064	Y2H Array	32296183
种属内	UBE2D2	P62837	RNF11	Homo sapiens	Q9Y3C5	Enzymatic Study	19549727
种属内	UBE2D2	P62837	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32296183
种属内	UBE2D2	P62837	RNF11	Homo sapiens	Q9Y3C5	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32296183
种属内	UBE2D2	P62837	PHF7	Homo sapiens	Q9BWX1	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	PHF7	Homo sapiens	Q9BWX1	Validated Y2H	32296183
种属内	UBE2D2	P62837	PHF7	Homo sapiens	Q9BWX1	Y2H Array	32296183
种属内	UBE2D2	P62837	XIAP	Homo sapiens	P98170	Enzymatic Study	19549727
种属内	UBE2D2	P62837	CUEDC1	Homo sapiens	Q9NWM3	Validated Y2H	32296183
种属内	UBE2D2	P62837	CUEDC1	Homo sapiens	Q9NWM3	Y2H Array	32296183
种属内	UBE2D2	P62837	CUEDC1	Homo sapiens	Q9NWM3	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	RNF10	Homo sapiens	Q8N5U6	Y2H Array	19549727
种属内	UBE2D2	P62837	RNF10	Homo sapiens	Q8N5U6	Anti Tag CoIP	33961781
种属内	UBE2D2	P62837	RNF10	Homo sapiens	Q8N5U6	Y2H	19549727
种属内	UBE2D2	P62837	RNF2	Homo sapiens	Q99496	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	RNF2	Homo sapiens	Q99496	Y2H Array	19549727
种属内	UBE2D2	P62837	RNF2	Homo sapiens	Q99496	Validated Y2H	32296183
种属内	UBE2D2	P62837	RNF2	Homo sapiens	Q99496	Y2H Array	32296183
种属内	UBE2D2	P62837	RNF114	Homo sapiens	Q9Y508	Y2H	19549727
种属内	UBE2D2	P62837	RNF114	Homo sapiens	Q9Y508	Anti Tag CoIP	33961781
种属内	UBE2D2	P62837	RNF114	Homo sapiens	Q9Y508	Y2H Array	19549727
种属内	UBE2D2	P62837	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
种属内	UBE2D2	P62837	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	DTX2	Homo sapiens	Q86UW9	Y2H Array	32296183
种属内	UBE2D2	P62837	UBTD1	Homo sapiens	Q9HAC8	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	UBTD1	Homo sapiens	Q9HAC8	Validated Y2H	32296183
种属内	UBE2D2	P62837	UBTD1	Homo sapiens	Q9HAC8	Y2H Array	32296183
种属内	UBE2D2	P62837	RING1	Homo sapiens	Q06587	Y2H Array	32296183
种属内	UBE2D2	P62837	RING1	Homo sapiens	Q06587	Y2H Prey Pooling	32296183
种属内	UBE2D2	P62837	RING1	Homo sapiens	Q06587	Y2H Array	19549727
种属内	UBE2D2	P62837	RING1	Homo sapiens	Q06587	Validated Y2H	32296183
种属内	UBE2D2	P62837	TRIM50	Homo sapiens	Q86XT4	Y2H Array	32296183
种属内	UBE2D2	P62837	TRIM50	Homo sapiens	Q86XT4	Validated Y2H	32296183
种属内	UBE2D2	P62837	TRIM50	Homo sapiens	Q86XT4	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBE2D2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P79449	UbcH5b/UBE2D2 Protein, Human	P62837-1 (M1-M147)	≥95%

关联疾病

疾病名称

别名

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Brachydactyly, Type E2

Brachydactyly Type E2	BDE2
Brachydactyly E2

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS24680	Ube2d2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS15340	UBE2D2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	UBE2D2	MGD	MGI:1930715
Bos taurus	UBE2D2	VGNC	VGNC:36580
Macaca mulatta	UBE2D2	VGNC	VGNC:84510
Rattus norvegicus	UBE2D2	RGD	RGD:1591897
Canis familiaris	UBE2D2	VGNC	VGNC:48051
Others	UBE2D2	NCBI

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