1. Gene
  2. DTX2 - deltex E3 ubiquitin ligase 2 Gene

DTX2 - deltex E3 ubiquitin ligase 2 Gene

中文名称:deltex E3 泛素连接酶 2

种属: Homo sapiens

同用名: RNF58

基因 ID: 113878 | 基因类型: protein coding

关于 DTX2

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:76,461,709-76,505,991 (from NCBI)

This gene has 21 transcripts (splice variants), 1 gene allele, 208 orthologues and 4 paralogues. Broad expression in esophagus (RPKM 8.4), testis (RPKM 7.2) and 25 other tissues.

功能概要

DTX2 作为 E3 泛素连接酶发挥作用 (Takeyama 等人,2003 [PubMed 12670957]) 。[OMIM 提供,2009 年 11 月]

DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

DTX2 基因产物(4)

mRNA Protein Name
NM_001102594.3 NP_001096064.1 probable E3 ubiquitin-protein ligase DTX2 isoform a
NM_001102595.3 NP_001096065.1 probable E3 ubiquitin-protein ligase DTX2 isoform a
NM_001102596.2 NP_001096066.1 probable E3 ubiquitin-protein ligase DTX2 isoform b
NM_020892.4 NP_065943.2 probable E3 ubiquitin-protein ligase DTX2 isoform a

DTX2 蛋白结构

WWE

WWE: WWE domain (15 - 97)

WWE

WWE: WWE domain (104 - 174)

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (412 - 472)

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蛋白主名 其他名称

probable E3 ubiquitin-protein ligase DTX2

RING-type E3 ubiquitin transferase DTX2

关联疾病

疾病名称 别名
Pthirus Pubis Infestation

Infestation By Phthirus Pubis

Crabs

Pediculosis Pubis

Pediculus Pubis

Phthiriasis Pubis

Phthirus Pubis

Phthirus/Pediculus Pubis - Pubic Lice - Crabs

Cutaneous Diphtheria

Diphtheria Wound Infection

Hypotrichosis 12

HYPT12

Hypotrichosis, Type 12

Embryonal Tumor With Multilayered Rosettes, C19mc-Altered

Ependymoblastoma

Atrophic Muscular Disease

Muscular Disorders, Atrophic

Coffin-Siris Syndrome 1

Coffin-Siris Syndrome

Fifth Digit Syndrome

Css

CSS1

Mrd12

Mental Retardation, Autosomal Dominant 12

Hhid

Dwarfism-Onychodysplasia

Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features

Autosomal Dominant Mental Retardation 12

Short Stature-Onychodysplasia.

Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx

Mental Retardation With Hypoplastic Fifth Fingernails And Toenails

Short Stature-Onychodysplasia

Coffin-Siris Syndrome, Type 1

Mental Retardation, Autosomal Dominant, Type 12

Cauda Equina Syndrome

Cauda Equina

Polyradiculopathy

Lice Infestation

Pediculosis

Louse Infestation

Mixed Pediculosis

Lice Infestations

Infestation By Pediculus

Mixed Pediculosis Infestation

Pediculosis + Lice

Pediculosis And Phthirus Infection

Pediculosis And Phthirus Infections

Pediculosis And Phthirus Infestation

Infestation By Anoplura

Pediculus Infestation

Lice Nos

Central Nervous System Primitive Neuroectodermal Neoplasm

Cpnet

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DTX2 VGNC VGNC:40116
Mus musculus DTX2 MGD MGI:1921448
Macaca mulatta DTX2 VGNC VGNC:71843
Bos taurus DTX2 VGNC VGNC:28237
Felis catus DTX2 VGNC VGNC:61649
Rattus norvegicus DTX2 RGD RGD:1561790