UCP3 - uncoupling protein 3 Gene

中文名称：解偶联蛋白 3

种属: Homo sapiens

同用名: SLC25A9

基因 ID: 7352 | 基因类型: protein coding

关于 UCP3

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,000,277-74,009,085 (from NCBI)

This gene has 4 transcripts (splice variants), 122 orthologues, 49 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

功能概要

线粒体解偶联蛋白 (UCP) 是更大的线粒体阴离子载体蛋白 (MACP) 家族的成员。 UCP 将氧化磷酸化与 ATP 合成分开，能量以热量形式消散，也称为线粒体质子泄漏。 UCP 促进阴离子从线粒体内膜转移到外膜，以及质子从线粒体外膜返回转移到线粒体内膜。它们还降低哺乳动物细胞中的线粒体膜电位。不同的 UCP 具有组织特异性表达；该基因主要在骨骼肌中表达。该基因的蛋白质产物被假定可保护线粒体免受脂质诱导的氧化应激。当供应给线粒体的脂肪酸超过其氧化能力时，该基因的表达水平会增加，并且该蛋白质能够从线粒体中输出脂肪酸。 UCP 包含通常在 MACP 中发现的三个 solcar 蛋白结构域。已发现该基因的两个剪接变体。[RefSeq 提供，2008 年 11 月]

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate Oxidative Phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]

UCP3 基因产物(2)

mRNA	Protein	Name
NM_003356.4	NP_003347.1	mitochondrial uncoupling protein 3 isoform UCP3L
NM_022803.3	NP_073714.1	mitochondrial uncoupling protein 3 isoform UCP3S

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables calcium ion transmembrane transporter activity	IMP IMP: 通过突变表型推断	21775425	GOA
NOT enables oxidative phosphorylation uncoupler activity	IDA IDA: 通过直接分析推断	11707458	GOA
enables oxidative phosphorylation uncoupler activity	IDA IDA: 通过直接分析推断	9305858	GOA
enables oxidative phosphorylation uncoupler activity	IMP IMP: 通过突变表型推断	21775425	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24008843	GOA
enables proton transmembrane transporter activity	IDA IDA: 通过直接分析推断	11171965	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in proton transmembrane transport	IDA IDA: 通过直接分析推断	11171965	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UCP3 蛋白结构

Mito_carr

0
100
200
312 a.a.

蛋白主名

其他名称

mitochondrial uncoupling protein 3

solute carrier family 25 member 9

UCP3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	UCP3	P55916	NS	Influenza A virus	P03495	Y2H	24008843
种属间	UCP3	P55916	NS	Influenza A virus	P03495	Pull Down	24008843

种属间: 跨种属相互作用 种属内: 同种属相互作用

UCP3 抗体

目录号	产品名	应用	反应物种
HY-P84409	UCP3 Antibody (YA4106)	ICC/IF, ELISA	Human

关联疾病

疾病名称

别名

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Leptin	Morbid Obesity Due To Leptin Deficiency
Obesity Morbid	Leptin Dysfunction

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Prediabetes Syndrome

Prediabetes	Impaired Glucose Tolerance
Prediabetic State	IGT
Igt - [Impaired Glucose Tolerance]	Impaired Glucose Tolerance With Unspecified Complication
Impaired Glucose Tolerance Without Complication	Abnormal Glucose Tolerance

Hyperinsulinism

Hyperinsulinemia

Diabetes Mellitus

Diabetes

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-117549	Ibrolipim	Activator	99.48%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15412	UCP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20349	Ucp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS26858	Ucp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	UCP3	VGNC	VGNC:36642
Rattus norvegicus	UCP3	RGD	RGD:3933
Mus musculus	UCP3	MGD	MGI:1099787
Macaca mulatta	UCP3	VGNC	VGNC:107661
Felis catus	UCP3	VGNC	VGNC:66800

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UCP3 - uncoupling protein 3 Gene

关于 UCP3

功能概要

UCP3 基因产物(2)

UCP3 蛋白结构

UCP3 蛋白互作信息

UCP3 抗体

关联疾病

直系同源

热门区域

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UCP3 - uncoupling protein 3 Gene

关于 UCP3

功能概要

UCP3 基因产物(2)

UCP3 蛋白结构

UCP3 蛋白互作信息

UCP3 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z