2. Gene
  3. Opa1 - OPA1, mitochondrial dynamin like GTPase Gene

Opa1 - OPA1, mitochondrial dynamin like GTPase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: lilr3; mKIAA0567; 1200011N24Rik

基因 ID: 74143 | 基因类型: protein coding

关于 Opa1

功能概要

Predicted to enable several functions, including GTPase activity; anion binding activity; and microtubule binding activity. Involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway and negative regulation of release of cytochrome c from mitochondria. Acts upstream of or within mitochondrial fusion and neural tube closure. Located in dendrite; mitochondrial inner membrane; and mitochondrial intermembrane space. Is expressed in several structures, including heart; liver; lung; skin; and visual system. Used to study optic atrophy. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial Dynamin like GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Opa1 基因产物(6)

mRNA Protein Name
NM_001199177.2 NP_001186106.1 dynamin-like 120 kDa protein, mitochondrial isoform 1
NM_001403170.1 NP_001390099.1 dynamin-like 120 kDa protein, mitochondrial isoform 3
NM_001403171.1 NP_001390100.1 dynamin-like 120 kDa protein, mitochondrial isoform 4
NM_001403172.1 NP_001390101.1 dynamin-like 120 kDa protein, mitochondrial isoform 4
NM_001403182.1 NP_001390111.1 dynamin-like 120 kDa protein, mitochondrial isoform 2
NM_133752.4 NP_598513.1 dynamin-like 120 kDa protein, mitochondrial isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase-dependent fusogenic activity IDA
IDA: 通过直接分析推断
28636943 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
21081504 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cristae formation IDA
IDA: 通过直接分析推断
25298396 MGI
involved in cristae formation IMP
IMP: 通过突变表型推断
24055366 MGI
involved in inner mitochondrial membrane organization IDA
IDA: 通过直接分析推断
28636943 MGI
involved in inner mitochondrial membrane organization IMP
IMP: 通过突变表型推断
36171294 MGI
involved in mitochondrial fusion IMP
IMP: 通过突变表型推断
15899901 MGI
involved in mitochondrial inner membrane fusion IDA
IDA: 通过直接分析推断
24703695 MGI
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
23453807 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
16839884 MGI
involved in negative regulation of release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
16839884 MGI
acts upstream of or within neural tube closure IMP
IMP: 通过突变表型推断
15755804 MGI
involved in positive regulation of T-helper 17 cell lineage commitment IMP
IMP: 通过突变表型推断
36171294 MGI
involved in positive regulation of interleukin-17 production IMP
IMP: 通过突变表型推断
36171294 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
11847212 MGI
is active in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
38225406 MGI
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
28746876 MGI
located in mitochondrial inner membrane IMP
IMP: 通过突变表型推断
16839884 MGI
is active in mitochondrial intermembrane space IDA
IDA: 通过直接分析推断
38225406 MGI
located in mitochondrial intermembrane space IDA
IDA: 通过直接分析推断
11847212 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
11847212 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

dynamin-like 120 kDa protein, mitochondrial

large GTP-binding protein

largeG

optic atrophy 1 homolog

optic atrophy protein 1 homolog

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126124 AP39 96.35% 否
HY-116364B AZT triphosphate tetraammonium 99.45% 否
HY-158162 SIRT3 activator 1 Activator 98.14% 否
HY-RS08281 MED12 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-116364 AZT triphosphate / 否
HY-116364A AZT triphosphate TEA / 否
HY-RS09789 OPA1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16968 Opa1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-131037 MB-0223 Inhibitor / 否
HY-RS18290 Med12 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23411 Opa1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Opa1 NCBI NCBI:4976
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