WNT9A - Wnt family member 9A Gene

中文名称：Wnt 家族成员 9A

种属: Homo sapiens

同用名: WNT14

基因 ID: 7483 | 基因类型: protein coding

关于 WNT9A

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:227,918,656-227,947,932 (from NCBI)

This gene has 1 transcript (splice variant), 216 orthologues and 18 paralogues. Broad expression in heart (RPKM 3.6), endometrium (RPKM 2.9) and 21 other tissues.

功能概要

Wnt 基因家族由编码分泌信号蛋白的结构相关基因组成。这些蛋白质与肿瘤发生和几个发育过程有关，包括胚胎发生过程中细胞命运和模式的调节。该基因是 Wnt 基因家族的成员。它在胃癌细胞系中表达。由该基因编码的蛋白质与鸡 Wnt14 具有 75% 的氨基酸同一性，后者已被证明在启动鸡肢滑膜关节形成中起着核心作用。该基因与染色体 1q42 区域的另一个家族成员 WNT3A 聚集在一起。[RefSeq 提供，2008 年 7 月]

The Wnt gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family. It is expressed in gastric Cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]

WNT9A 基因产物(1)

mRNA	Protein	Name
NM_003395.4	NP_003386.1	protein Wnt-9a precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables receptor ligand activity	IDA IDA: 通过直接分析推断	28733458	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	28733458	GOA
involved in negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	17351820	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WNT9A 蛋白结构

wnt

0
100
200
300
365 a.a.

蛋白主名

其他名称

protein Wnt-9a

wingless-type MMTV integration site family, member 14

WNT9A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	WNT9A	O14904	ZBTB14	Homo sapiens	O43829	Y2H Prey Pooling	32296183
种属内	WNT9A	O14904	ZBTB14	Homo sapiens	O43829	Validated Y2H	32296183
种属内	WNT9A	O14904	ZBTB14	Homo sapiens	O43829	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mullerian Aplasia And Hyperandrogenism

Mullerian Duct Failure And Hyperandrogenism	Wnt4 Deficiency
Müllerian Aplasia And Hyperandrogenism	Biason-Lauber Syndrome
Mayer-Rokitansky-Küster-Hauser-Biason-Lauber Syndrome	Mayer-Rokitansky-Küster-Hauser-Like Syndrome
Müllerian Duct Failure	Wnt4 Müllerian Aplasia
Wnt4 Müllerian Aplasia And Ovarian Dysfunction	MULLAPL
Wnt4 Mullerian Aplasia And Ovarian Dysfunction

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Proximal Symphalangism

Cushing'S Symphalangism	Symphalangism, Proximal
Hereditary Absence Of Proximal Interphalangeal Joints	Strasburger-Hawkins-Eldridge Syndrome
Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome	Symphalangism, Proximal, 1a
Symphalangism, Proximal, 1b	Vessel'S Syndrome
Symphalangism, Cushing Type

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15844	WNT9A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	WNT9A	VGNC	VGNC:54801
Rattus norvegicus	WNT9A	RGD	RGD:1305018
Bos taurus	WNT9A	VGNC	VGNC:36966
Macaca mulatta	WNT9A	VGNC	VGNC:78796
Mus musculus	WNT9A	MGD	MGI:2446084
Felis catus	WNT9A	VGNC	VGNC:102363

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