2. Gene
  3. YES1 - YES proto-oncogene 1, Src family tyrosine kinase Gene

YES1 - YES proto-oncogene 1, Src family tyrosine kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：YES 原癌基因 1，Src 家族酪氨酸激酶

种属: Homo sapiens

同用名: Yes; c-yes; HsT441; P61-YES

基因 ID: 7525 | 基因类型: protein coding

关于 YES1

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:721,588-812,753 (from NCBI)

This gene has 5 transcripts (splice variants), 261 orthologues and 32 paralogues. Ubiquitous expression in placenta (RPKM 22.4), fat (RPKM 16.6) and 25 other tissues.

功能概要

该基因是山口肉瘤病毒致癌基因的细胞同系物。编码的蛋白质具有酪氨酸激酶活性，属于 Src 蛋白质家族。该基因与 18 号染色体上的胸苷酸合酶基因非常接近，并且在 22 号染色体上发现了相应的假基因。[RefSeq 提供，2008 年 7 月]

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the Src family of proteins. This gene lies in close proximity to Thymidylate Synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

YES1 基因产物(1)

mRNA Protein Name
NM_005433.4 NP_005424.1 tyrosine-protein kinase Yes

YES1 蛋白结构

SH3_1

SH3_1: SH3 domain (97 - 144)

SH2

SH2: SH2 domain (158 - 240)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (278 - 526)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 543 a.a.
蛋白主名 其他名称

tyrosine-protein kinase Yes

YES1 proto-oncogene, Src family tyrosine kinase

重组 YES1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73486 YES1 Protein, Human (sf9, His-GST) P07947 (G2-L543) ≥95%

关联疾病

疾病名称 别名
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Co-Trimoxazole Allergy

Bactrim Allergy

Cotrimoxazol Allergy

Tmp/Smx Allergy

Trimethoprim/Sulfamethoxazole Allergy
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136848 SM1-71 Inhibitor 96.00% 否
HY-135299 CH6953755 Inhibitor 98.03% 否
HY-145373 BMS-986143 Inhibitor / 否
HY-RS15922 YES1 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus YES1 RGD RGD:3977
Bos taurus YES1 VGNC VGNC:37022
Canis familiaris YES1 VGNC VGNC:48484
Mus musculus YES1 MGD MGI:99147
Macaca mulatta YES1 VGNC VGNC:78817
Felis catus YES1 VGNC VGNC:67136
Others YES1 NCBI
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