1. Gene
  2. YWHAH - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta Gene

YWHAH - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta Gene

中文名称:酪氨酸 3-单加氧酶/色氨酸 5-单加氧酶激活蛋白 eta

种属: Homo sapiens

同用名: YWHA1

基因 ID: 7533 | 基因类型: protein coding

关于 YWHAH

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:31,944,535-31,957,603 (from NCBI)

This gene has 6 transcripts (splice variants), 124 orthologues and 6 paralogues. Broad expression in brain (RPKM 343.5), lung (RPKM 62.6) and 22 other tissues.

功能概要

该基因产物属于 14-3-3 蛋白家族,通过与含磷酸丝氨酸的蛋白结合来介导信号转导。这种高度保守的蛋白质家族存在于植物和哺乳动物中,并且这种蛋白质与小鼠、大鼠和牛的直系同源物具有 99% 的相同性。该基因在其 5' UTR 中包含一个 7 bp 的重复序列,该重复序列数量的变化与早发性精神分裂症和精神病性双相情感障碍有关。[RefSeq 提供,2009 年 6 月]

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]

YWHAH 基因产物(1)

mRNA Protein Name
NM_003405.4 NP_003396.1 2014/3/3 protein eta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
17255105 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17085597 GOA
enables nuclear glucocorticoid receptor binding IPI
IPI: 通过物理相互作用推断
9079630 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10713667 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
11953308 GOA
enables sodium channel regulator activity IDA
IDA: 通过直接分析推断
16728661 GOA
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
11953308 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glucocorticoid catabolic process IDA
IDA: 通过直接分析推断
15790729 GOA
involved in membrane depolarization during action potential IDA
IDA: 通过直接分析推断
16728661 GOA
involved in nuclear receptor-mediated glucocorticoid signaling pathway IDA
IDA: 通过直接分析推断
15790729 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15790729 GOA
involved in regulation of sodium ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
16728661 GOA
involved in regulation of sodium ion transport IDA
IDA: 通过直接分析推断
16728661 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
31906564 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
16728661 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

YWHAH 蛋白结构

14-3-3

14-3-3: 14-3-3 protein (4 - 241)

  • 0
  • 100
  • 200
  • 246 a.a.
蛋白主名 其他名称

14-3-3 protein eta

14-3-3 eta

YWHAH 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
YWHAH Q04917 CDK14 Homo sapiens O94921 28514442
种属内
YWHAH Q04917 CDK14 Homo sapiens O94921
Y2H
16775625
种属内
YWHAH Q04917 CDK14 Homo sapiens O94921 36931259
种属内
YWHAH Q04917 CCNY Homo sapiens Q8ND76 28514442
种属内
YWHAH Q04917 CDC25B Homo sapiens P30305 36931259
种属内
YWHAH Q04917 CDC25B Homo sapiens P30305 28514442
种属内
YWHAH Q04917 CDC25B Homo sapiens P30305
Y2H
10713667
种属内
YWHAH Q04917 INPP5E Homo sapiens Q9NRR6 36931259
种属内
YWHAH Q04917 INPP5E Homo sapiens Q9NRR6 28514442
种属内
YWHAH Q04917 INPP5E Homo sapiens Q9NRR6 35271311
种属内
YWHAH Q04917 CCDC125 Homo sapiens Q86Z20 32296183
种属内
YWHAH Q04917 PRKD2 Homo sapiens Q9BZL6 17962809
种属内
YWHAH Q04917 PRKD2 Homo sapiens Q9BZL6 28514442
种属内
YWHAH Q04917 PRR5 Homo sapiens P85299 28514442
种属内
YWHAH Q04917 PRR5 Homo sapiens P85299 36931259
种属内
YWHAH Q04917 SSX2IP Homo sapiens Q9Y2D8 36931259
种属内
YWHAH Q04917 SSX2IP Homo sapiens Q9Y2D8 28514442
种属内
YWHAH Q04917 SSX2IP Homo sapiens Q9Y2D8 36931259
种属内
YWHAH Q04917 SPG11 Homo sapiens Q96JI7
Y2H
37871017
种属内
YWHAH Q04917 NHSL2 Homo sapiens Q5HYW2 32296183
种属内
YWHAH Q04917 PRKCI Homo sapiens P41743 14676191
种属内
YWHAH Q04917 PRKCI Homo sapiens P41743
TAP
17979178
种属内
YWHAH Q04917 PRKCI Homo sapiens P41743 36931259
种属内
YWHAH Q04917 PARD6B Homo sapiens Q9BYG5 14676191
种属内
YWHAH Q04917 PARD6G Homo sapiens Q9BYG4 14676191
种属内
YWHAH Q04917 MARK4 Homo sapiens Q96L34 16959763
种属内
YWHAH Q04917 MARK4 Homo sapiens Q96L34 36931259
种属内
YWHAH Q04917 MARK4 Homo sapiens Q96L34 14676191
种属内
YWHAH Q04917 RAF1 Homo sapiens P04049 26496610
种属内
YWHAH Q04917 RAF1 Homo sapiens P04049 33961781
种属内
YWHAH Q04917 RAF1 Homo sapiens P04049 36931259
种属内
YWHAH Q04917 RAF1 Homo sapiens P04049 28514442
种属内
YWHAH Q04917 RAF1 Homo sapiens P04049
TAP
17979178
种属内
YWHAH Q04917 RAF1 Homo sapiens P04049 11697890
种属内
YWHAH Q04917 RAF1 Homo sapiens P04049 35271311
种属内
YWHAH Q04917 MAP3K3 Homo sapiens Q99759 36931259
种属内
YWHAH Q04917 MAP3K3 Homo sapiens Q99759 28514442
种属内
YWHAH Q04917 MAP3K3 Homo sapiens Q99759 33961781
种属内
YWHAH Q04917 HDAC4 Homo sapiens P56524 18045992
种属内
YWHAH Q04917 HDAC4 Homo sapiens P56524 36931259
种属内
YWHAH Q04917 HDAC4 Homo sapiens P56524 33961781
种属内
YWHAH Q04917 HDAC4 Homo sapiens P56524 36931259
种属内
YWHAH Q04917 HDAC4 Homo sapiens P56524 26496610
种属内
YWHAH Q04917 HDAC4 Homo sapiens P56524 28514442
种属内
YWHAH Q04917 HDAC4 Homo sapiens P56524
TAP
17979178
种属内
YWHAH Q04917 YWHAE Homo sapiens P62258 28514442
种属内
YWHAH Q04917 YWHAE Homo sapiens P62258 36931259
种属内
YWHAH Q04917 YWHAE Homo sapiens P62258 26496610
种属内
YWHAH Q04917 YWHAE Homo sapiens P62258 35271311
种属内
YWHAH Q04917 YWHAE Homo sapiens P62258 20936779
种属内
YWHAH Q04917 YWHAE Homo sapiens P62258 36931259
种属内
YWHAH Q04917 YWHAE Homo sapiens P62258 36931259
种属内
YWHAH Q04917 YWHAE Homo sapiens P62258 33961781
种属内
YWHAH Q04917 NEK1 Homo sapiens Q96PY6 33961781
种属内
YWHAH Q04917 NEK1 Homo sapiens Q96PY6 28514442
种属内
YWHAH Q04917 NEK1 Homo sapiens Q96PY6 36931259
种属内
YWHAH Q04917 NEK1 Homo sapiens Q96PY6
Y2H
14690447
种属内
YWHAH Q04917 NEK1 Homo sapiens Q96PY6 35271311
种属内
YWHAH Q04917 FGD6 Homo sapiens Q6ZV73 36931259
种属内
YWHAH Q04917 FGD6 Homo sapiens Q6ZV73 28514442
种属内
YWHAH Q04917 FGD6 Homo sapiens Q6ZV73 36931259
种属内
YWHAH Q04917 MAP3K5 Homo sapiens Q99683 33961781
种属内
YWHAH Q04917 MAP3K5 Homo sapiens Q99683 28514442
种属内
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7
TAP
17979178
种属内
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7 36931259
种属内
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7 14676191
种属内
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7 33961781
种属内
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7 28514442
种属内
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7 16959763
种属内
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7 19553522
种属内
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7 36931259
种属内
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7 35271311
种属内
YWHAH Q04917 CBL Homo sapiens P22681 33961781
种属内
YWHAH Q04917 CBL Homo sapiens P22681 28514442
种属内
YWHAH Q04917 CBL Homo sapiens P22681 36931259
种属内
YWHAH Q04917 CBL Homo sapiens P22681 11697890
种属内
YWHAH Q04917 KANK1 Homo sapiens Q14678-2 18458160
种属内
YWHAH Q04917 CAMKK1 Homo sapiens Q8N5S9 18242179
种属内
YWHAH Q04917 CAMKK1 Homo sapiens Q8N5S9 18242179
种属内
YWHAH Q04917 CAMKK1 Homo sapiens Q8N5S9 36931259
种属间
YWHAH Q04917 Rnd3 Mus musculus P61588 23622247
种属内
YWHAH Q04917 BAD Homo sapiens Q92934 33961781
种属内
YWHAH Q04917 BAD Homo sapiens Q92934 36931259
种属内
YWHAH Q04917 BAD Homo sapiens Q92934
Y2H
21988832
种属内
YWHAH Q04917 BAD Homo sapiens Q92934 28514442
种属内
YWHAH Q04917 BAD Homo sapiens Q92934
TAP
17979178
种属内
YWHAH Q04917 MARK3 Homo sapiens P27448 28514442
种属内
YWHAH Q04917 MARK3 Homo sapiens P27448 14676191
种属内
YWHAH Q04917 MARK3 Homo sapiens P27448
TAP
17979178
种属内
YWHAH Q04917 MARK3 Homo sapiens P27448 36931259
种属内
YWHAH Q04917 MARK3 Homo sapiens P27448 35271311
种属内
YWHAH Q04917 MARK3 Homo sapiens P27448 36931259
种属内
YWHAH Q04917 MARK3 Homo sapiens P27448 33961781
种属内
YWHAH Q04917 NEDD4L Homo sapiens Q96PU5 36931259
种属内
YWHAH Q04917 NEDD4L Homo sapiens Q96PU5 15677482
种属内
YWHAH Q04917 NEDD4L Homo sapiens Q96PU5 33961781
种属内
YWHAH Q04917 NEDD4L Homo sapiens Q96PU5 36931259
种属内
YWHAH Q04917 NEDD4L Homo sapiens Q96PU5 28514442
种属内
YWHAH Q04917 AKT1S1 Homo sapiens Q96B36
TAP
17979178
种属内
YWHAH Q04917 AKT1S1 Homo sapiens Q96B36 36931259
种属内
YWHAH Q04917 AKT1S1 Homo sapiens Q96B36 33961781
种属内
YWHAH Q04917 AKT1S1 Homo sapiens Q96B36 28514442
种属内
YWHAH Q04917 PLK4 Homo sapiens O00444 28514442
种属内
YWHAH Q04917 CSNK1E Homo sapiens P49674 19860830
种属内
YWHAH Q04917 CSNK1E Homo sapiens P49674 36931259
种属内
YWHAH Q04917 CSNK1E Homo sapiens P49674 36931259
种属内
YWHAH Q04917 PARD6A Homo sapiens Q9NPB6 14676191
种属内
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0 33961781
种属内
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0 28514442
种属内
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0 14676191
种属内
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0
TAP
17979178
种属内
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0 36931259
种属内
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0 35271311
种属内
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0 36931259
种属内
YWHAH Q04917 ATXN1 Homo sapiens P54253 28514442
种属内
YWHAH Q04917 ATXN1 Homo sapiens P54253 36931259
种属内
YWHAH Q04917 SNCA Homo sapiens P37840-1
FPS
24895406
种属内
YWHAH Q04917 SNCA Homo sapiens P37840-1
AFM
24895406
种属内
YWHAH Q04917 SNCA Homo sapiens P37840-1
TEM
24895406
种属内
YWHAH Q04917 SNCA Homo sapiens P37840-1 24895406
种属内
YWHAH Q04917 SNCA Homo sapiens P37840 24895406
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 YWHAH 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71682 14-3-3 eta Protein, Human (GST) Q04917 (R4-N246) ≥95%

YWHAH 抗体

目录号 产品名 应用 反应物种
HY-P80525 14-3-3 eta Antibody (YA838) WB Human, Mouse, Rat
HY-P85780 14-3-3 eta Antibody (YA5472) WB, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Early-Onset Schizophrenia

Early Onset Schizophrenia

Deafness, Autosomal Dominant 64

DFNA64

Autosomal Dominant Nonsyndromic Deafness 64

Autosomal Dominant Deafness 64

Deafness, Autosomal Dominant, 64

Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 64

Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 64

Deafness, Autosomal Dominant, Type 64

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Small Intestine Leiomyosarcoma

Leiomyosarcoma Of The Small Bowel

Smooth Muscle Connective Tissue Tumor

Leiomyosarcoma Of Small Intestine

Neurofibromatosis, Type I

Von Recklinghausen Disease

Neurofibromatosis 1

Neurofibromatosis, Type 1

NF1

Neurofibromatosis, Peripheral Type

Neurofibromatosis Type I

Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion

Familial Spinal Neurofibromatosis

Fsnf

Peripheral Neurofibromatosis

Von Recklinghausen'S Neurofibromatosis

Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion

Neurofibromatosis Peripheral Type

Von Recklinghausen Syndrome

Neurofibromatosis Type 1

Von Recklinghausen Neuropathy

Nf1 - [Neurofibromatosis Type 1]

Recklinghausen Disease

Sudden Infant Death Syndrome

SIDS

Sudden Infant Death Syndrome, Susceptibility To

Cot Death

Crib Death

Sudden Death Of Nonspecific Cause In Infancy

Sudden Infant Death

Death, Sudden, Syndrome, Infant

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris YWHAH VGNC VGNC:52975
Macaca mulatta YWHAH VGNC VGNC:78821
Mus musculus YWHAH MGD MGI:109194
Felis catus YWHAH VGNC VGNC:67156
Bos taurus YWHAH VGNC VGNC:97330
Rattus norvegicus YWHAH RGD RGD:3978
Others YWHAH NCBI