Ern1 - endoplasmic reticulum (ER) to nucleus signalling 1 Gene

中文名称：内质网 (ER) 到细胞核信号 1

种属: Mus musculus

同用名: Ire1a; Ire1p; Ire1alpha; 9030414B18Rik

关于 Ern1

功能概要

该基因编码的蛋白可启动核糖核酸内切酶活性；蛋白质同二聚化活性；和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括 IRE1 介导的未折叠蛋白反应； mRNA 裂解；氮化合物代谢过程的正向调控。作用于内质网未折叠蛋白反应的上游或内部；响应内质网应激的内在凋亡信号通路；和蛋白质自身磷酸化。位于内质网膜；线粒体；和核内膜。 AIP1-IRE1 复合体的一部分。以多种结构表达，包括大脑；结缔组织;直觉;淋巴系统腺体；和牙齿。该基因的人类直系同源物与肝细胞癌有关。与人类 ERN1（内质网到细胞核信号转导 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables endoribonuclease activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including IRE1-mediated unfolded protein response; mRNA cleavage; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within endoplasmic reticulum unfolded protein response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and protein autophosphorylation. Located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Part of AIP1-IRE1 complex. Is expressed in several structures, including brain; connective tissue; gut; hemolymphoid system gland; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1). [provided by Alliance of Genome Resources, Apr 2022]