2. Gene
  3. Atf4 - activating transcription factor 4 Gene

Atf4 - activating transcription factor 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 79255 | 基因类型: protein coding

关于 Atf4

功能概要

Enables DNA-binding transcription factor binding activity; general transcription initiation factor binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to oxygen-glucose deprivation; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; and response to manganese-induced endoplasmic reticulum stress. Located in cytoplasm; dendrite membrane; and nucleus. Biomarker of borna disease and pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Atf4 基因产物(1)

mRNA Protein Name
NM_024403.2 NP_077379.1 cyclic AMP-dependent transcription factor ATF-4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
18171674 RGD
enables general transcription initiation factor binding IPI
IPI: 通过物理相互作用推断
18171674 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10924501 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
20444431 RGD
involved in cellular response to oxidative stress IMP
IMP: 通过突变表型推断
23392669 RGD
involved in gamma-aminobutyric acid signaling pathway IDA
IDA: 通过直接分析推断
10924501 RGD
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
23392669 RGD
involved in negative regulation of potassium ion transport IMP
IMP: 通过突变表型推断
10924501 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
19322020 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23392669 RGD
involved in response to manganese-induced endoplasmic reticulum stress IEP
IEP: 通过表达模式推断
23934647 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
20026213 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite membrane IDA
IDA: 通过直接分析推断
10924501 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cyclic AMP-dependent transcription factor ATF-4

activating transcription factor 4 (tax-responsive enhancer element B67)

activating transcription factor ATF-4

cAMP-dependent transcription factor ATF-4

rATF-4

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-13559 Atiprimod / Phase 2
HY-13559A Atiprimod dimaleate / Phase 2
Pre-clinical Phase
生物活性分子 (30)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100355 C18-Ceramide 99.95% 否
HY-100548 GSK621 98.03% 否
HY-158201 ATF4-IN-1 Activator 99.29% 否
HY-158202 ATF4-IN-2 Inhibitor 99.24% 否
HY-153339 E235 Activator 99.86% 否
HY-153340 I-152 Activator 98.78% 否
HY-170872 PT-129 98.66% 否
HY-112056 DIM-C-pPhCO2Me 99.47% 否
HY-153074 ISR-IN-1 98.92% 否
HY-W020952 Palladium(Ⅱ) acetylacetonate 98.2% 否
HY-124646 KIRA-7 Inhibitor 99.09% 否
HY-153075 ISR-IN-2 98.21% 否
HY-121337 Flurochloridone 99.61% 否
HY-158203 BMP agonist 2 Agonist 99.26% 否
HY-158196 PERK/eIF2α activator 1 Activator 98.88% 否
HY-RS01130 ATF4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-149918 Antiproliferative agent-23 / 否
HY-112654A GCN2iB acetate / 否
HY-117938 T-3861174 Inhibitor / 否
HY-158195 DPP23 99.55% 否
HY-158205 HPO-DAEE / 否
HY-162886 BSO-07 Activator / 否
HY-170849 Nur77 modulator 4 Inducer / 否
HY-172784 Anticancer agent 273 / 否
HY-178154 FB231 / 否
HY-110102 Atiprimod hydrochloride / 否
HY-112903A YW3-56 hydrochloride / 否
HY-138844 3-AP-Me Activator / 否
HY-RS16552 Atf4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22985 Atf4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atf4 NCBI NCBI:468
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z