2. Cell Cycle/DNA Damage
  3. IRE1
  4. KIRA-7

KIRA-7 是一种咪唑并吡嗪化合物，可与 IRE1α 激酶结合 (IC50 为 110 nM) 以变构方式抑制其 RNase 活性。KIRA-7 具有抗纤维化作用。

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KIRA-7 Chemical Structure

KIRA-7 Chemical Structure

CAS No. : 1937235-76-1

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规格 价格 是否有货 数量
1 mg ￥1863
In-stock
5 mg ￥4100
In-stock
10 mg ￥6700
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

KIRA-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect[1].

IC50 & Target

IC50: 110 nM (IRE1α kinase)[1]
体外研究
(In Vitro)

KIRA-7 can inhibit XBP1 splicing in the alveolar epithelial cell line MLE12[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KIRA-7 相关抗体:
体内研究
(In Vivo)

KIRA-7 (5 mg/kg; intraperitoneal injection; daily for 14 days; C57BL6 mice) treatment results in decreased spliced XBP1 and ATF4, compared to bleomycin exposed mice treated with vehicle. Likewise, mRNA levels of BiP and CHOP are significantly elevated after Bleomycin exposure, and treatment of Bleomycin-exposed mice with KIRA-7 decreased these levels. mRNA levels of collagen 1A1 and fibronectin are both significantly decreased by KIRA-7 treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL6 mice (12 weeks of age) with Bleomycin (1.5 units/kg)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; daily; for 14 days
Result: Resulted in decreased spliced XBP1 and ATF4. Likewise, mRNA levels of BiP and CHOP were significantly decreased.
分子量

466.51

Formula

C27H23FN6O
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (214.36 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1436 mL 10.7179 mL 21.4358 mL
5 mM 0.4287 mL 2.1436 mL 4.2872 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

KIRA-7 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1436 mL 10.7179 mL 21.4358 mL 53.5894 mL
5 mM 0.4287 mL 2.1436 mL 4.2872 mL 10.7179 mL
10 mM 0.2144 mL 1.0718 mL 2.1436 mL 5.3589 mL
15 mM 0.1429 mL 0.7145 mL 1.4291 mL 3.5726 mL
20 mM 0.1072 mL 0.5359 mL 1.0718 mL 2.6795 mL
25 mM 0.0857 mL 0.4287 mL 0.8574 mL 2.1436 mL
30 mM 0.0715 mL 0.3573 mL 0.7145 mL 1.7863 mL
40 mM 0.0536 mL 0.2679 mL 0.5359 mL 1.3397 mL
50 mM 0.0429 mL 0.2144 mL 0.4287 mL 1.0718 mL
60 mM 0.0357 mL 0.1786 mL 0.3573 mL 0.8932 mL
80 mM 0.0268 mL 0.1340 mL 0.2679 mL 0.6699 mL
100 mM 0.0214 mL 0.1072 mL 0.2144 mL 0.5359 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIRA-71937235-76-1KIRA7KIRA 7IRE1Inositol requiring enzyme 1IRE1αfibrosisXBP1 ATF4BiPCHOPcollagen-1A1fibronectinER stressInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-124646
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