2. Gene
  3. NOX5 - NADPH oxidase 5 Gene

NOX5 - NADPH oxidase 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：NADPH 氧化酶 5

种属: Homo sapiens

基因 ID: 79400 | 基因类型: protein coding

关于 NOX5

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:68,930,525-69,062,762 (from NCBI)

This gene has 6 transcripts (splice variants), 150 orthologues and 6 paralogues. Biased expression in spleen (RPKM 7.9), testis (RPKM 4.2) and 3 other tissues.

功能概要

该基因主要在睾丸和脾脏和淋巴结的富含淋巴细胞的区域表达。它编码产生超氧化物的钙依赖性 NADPH 氧化酶，并作为钙依赖性质子通道发挥作用，可调节淋巴细胞和精子中的氧化还原依赖性过程。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 10 月]

This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH Oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

NOX5 基因产物(3)

mRNA Protein Name
NM_001184779.2 NP_001171708.1 NADPH oxidase 5 isoform 2
NM_001184780.2 NP_001171709.1 NADPH oxidase 5 isoform 3
NM_024505.4 NP_078781.3 NADPH oxidase 5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17346712 GOA
enables proton channel activity IDA
IDA: 通过直接分析推断
11483596 GOA
NOT contributes to superoxide-generating NAD(P)H oxidase activity IDA
IDA: 通过直接分析推断
22427510 GOA
enables superoxide-generating NAD(P)H oxidase activity IDA
IDA: 通过直接分析推断
11483596 GOA
enables superoxide-generating NAD(P)H oxidase activity IMP
IMP: 通过突变表型推断
14982937 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IDA
IDA: 通过直接分析推断
17275676 GOA
involved in endothelial cell proliferation IDA
IDA: 通过直接分析推断
17275676 GOA
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: 通过直接分析推断
17275676 GOA
involved in proton transmembrane transport IDA
IDA: 通过直接分析推断
11483596 GOA
involved in superoxide anion generation IDA
IDA: 通过直接分析推断
11483596 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
17275676 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17587483 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOX5 蛋白结构

EF-hand_6

EF-hand_6: EF-hand domain (63 - 87)

EF-hand_5

EF-hand_5: EF hand (173 - 191)

Ferric_reduct

Ferric_reduct: Ferric reductase like transmembrane component (272 - 413)

FAD_binding_8

FAD_binding_8: FAD-binding domain (445 - 574)

NAD_binding_6

NAD_binding_6: Ferric reductase NAD binding domain (583 - 753)

  • 0
  • 200
  • 400
  • 600
  • 765 a.a.
蛋白主名 其他名称

NADPH oxidase 5

NADPH oxidase, EF-hand calcium binding domain 5

关联疾病

疾病名称 别名
Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine
Barrett'S Adenocarcinoma

Barrett Adenocarcinoma

Adenocarcinoma Arising In Barrett'S Mucosa
Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-174818 NOX5-IN-2 Inhibitor / 否
HY-174817 NOX5-IN-1 Inhibitor / 否
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