2. Gene
  3. KDM8 - lysine demethylase 8 Gene

KDM8 - lysine demethylase 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：赖氨酸脱甲基酶 8

种属: Homo sapiens

同用名: JMJD5

基因 ID: 79831 | 基因类型: protein coding

关于 KDM8

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:27,203,526-27,221,768 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and 4 paralogues. Broad expression in liver (RPKM 13.5), small intestine (RPKM 5.4) and 18 other tissues.

功能概要

该基因可能编码组蛋白赖氨酸脱甲基酶。对小鼠中类似蛋白质的研究表明该蛋白质具有作为肿瘤抑制因子的潜在作用。已经描述了可变剪接的转录变体。[RefSeq 提供，2009 年 2 月]

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

KDM8 基因产物(2)

mRNA Protein Name
NM_001145348.2 NP_001138820.1 bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 1
NM_024773.3 NP_079049.2 bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aminopeptidase activity IDA
IDA: 通过直接分析推断
28847961 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
20457893 GOA
enables endopeptidase activity IDA
IDA: 通过直接分析推断
28847961 GOA
enables histone H3K36 demethylase activity IDA
IDA: 通过直接分析推断
20457893 GOA
enables methylated histone binding IDA
IDA: 通过直接分析推断
28847961 GOA
enables peptidyl-arginine 3-dioxygenase activity EXP
EXP: 通过实验结果推断
29563586 GOA
enables peptidyl-arginine 3-dioxygenase activity IDA
IDA: 通过直接分析推断
29563586 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24981860 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
20457893 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
30500822 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
20457893 GOA
involved in protein destabilization IMP
IMP: 通过突变表型推断
30500822 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
20457893 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KDM8 蛋白结构

Cupin_8

Cupin_8: Cupin-like domain (194 - 415)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
蛋白主名 其他名称

bifunctional peptidase and arginyl-hydroxylase JMJD5

JmjC arginyl-hydroxylase

KDM8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KDM8 Q8N371 RCCD1 Homo sapiens A6NED2
Anti Bait CoIP
24981860
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Glycogen Storage Disease Xv

GSD15

Gsd Xv

Glycogenin Deficiency

Gyg1 Deficiency

Glycogen Storage Disease Type Xv

Glycogen Storage Disease With Severe Cardiomyopathy Due To Glycogenin Deficiency

Gsd Type 15

Gsd Type Xv

Gsd With Severe Cardiomyopathy Due To Glycogenin Deficiency

Glycogen Storage Disease Type 15

Glycogenosis Type 15

Glycogenosis Type Xv

Glycogenosis With Severe Cardiomyopathy Due To Glycogenin Deficiency

Glycogen Storage Disease 15

Storage Disease, Glycogen, Type Xv
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07225 KDM8 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20759 Kdm8 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27272 Kdm8 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus KDM8 VGNC VGNC:80586
Mus musculus KDM8 MGD MGI:1924285
Bos taurus KDM8 VGNC VGNC:30534
Canis familiaris KDM8 VGNC VGNC:42330
Macaca mulatta KDM8 VGNC VGNC:81426
Rattus norvegicus KDM8 RGD RGD:1304823
Others KDM8 NCBI
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