2. Gene
  3. PLA2G12A - phospholipase A2 group XIIA Gene

PLA2G12A - phospholipase A2 group XIIA Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酶 A2 XIIA 组

种属: Homo sapiens

同用名: GXII; ROSSY; PLA2G12

基因 ID: 81579 | 基因类型: protein coding

关于 PLA2G12A

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:109,709,989-109,730,070 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 11.6), prostate (RPKM 9.6) and 25 other tissues.

功能概要

分泌型磷脂酶 A2 (sPLA2) 酶从磷脂中释放花生四烯酸以产生类花生酸并发挥多种生理和病理作用。第 XII 组 sPLA2，例如 PLA2G12A，具有相对较低的比活性，并且在结构和功能上与其他 sPLA2 不同 (Gelb 等人，2000 [PubMed 11031251]) 。[OMIM 提供，2008 年 3 月]

Secreted Phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from Phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]

PLA2G12A 基因产物(1)

mRNA Protein Name
NM_030821.5 NP_110448.2 group XIIA secretory phospholipase A2 precursor

PLA2G12A 蛋白结构

PLA2G12

PLA2G12: Group XII secretory phospholipase A2 precursor (PLA2G12) (17 - 189)

  • 0
  • 100
  • 189 a.a.
蛋白主名 其他名称

group XIIA secretory phospholipase A2

GXII sPLA2

关联疾病

疾病名称 别名
Coenzyme Q10 Deficiency, Primary, 9

COQ10D9

Primary Coenzyme Q10 Deficiency 9
Cerebrooculofacioskeletal Syndrome 1

Cofs Syndrome

COFS1

Pena-Shokeir Syndrome Type 2

Cofs

Pena-Shokeir Syndrome, Type Ii

Cerebrooculofacioskeletal Syndrome

Cerebro-Oculo-Facio-Skeletal Syndrome 1

Pena Shokeir Syndrome Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10617 PLA2G12A Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PLA2G12A VGNC VGNC:64197
Bos taurus PLA2G12A VGNC VGNC:32954
Macaca mulatta PLA2G12A VGNC VGNC:76058
Rattus norvegicus PLA2G12A RGD RGD:1304662
Mus musculus PLA2G12A MGD MGI:1913600
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