1. Gene
  2. Gak - cyclin G associated kinase Gene

Gak - cyclin G associated kinase Gene

中文名称:细胞周期蛋白G相关激酶

种属: Rattus norvegicus

基因 ID: 81659 | 基因类型: protein coding

关于 Gak

Primary_assembly 14: 1,089,866-1,216,398 forward strand.mRatBN7.2:CM026987.1

This gene has 4 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 26.3), Thymus (RPKM 193.3) and 9 other tissues.

功能概要

该基因编码的蛋白可启动细胞周期蛋白结合活性。预计参与多个过程,包括高尔基体到溶酶体的运输;网格蛋白涂层拆卸;和网格蛋白涂层的坑组件。预计在多个过程的上游或内部起作用,包括高尔基组织;动物器官发育;和神经前体细胞增殖的正调节。预测位于高尔基体。预计在细胞质中有活性;细胞内膜结合细胞器;和囊泡。与人类 GAK(细胞周期蛋白 G 相关激酶)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables cyclin binding activity. Predicted to be involved in several processes, including Golgi to lysosome transport; clathrin coat disassembly; and clathrin-coated pit assembly. Predicted to act upstream of or within several processes, including Golgi organization; animal organ development; and positive regulation of neural precursor cell proliferation. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Orthologous to human GAK (cyclin G associated kinase). [provided by Alliance of Genome Resources, Apr 2022]

Gak 基因产物(1)

mRNA Protein Name
NM_031030.2 NP_112292.1 cyclin-G-associated kinase

Gak 蛋白结构

STKc_GAK

STKc_GAK: cd14036 (38 - 319)

PTP_GAK

PTP_GAK: cd14564 (397 - 559)

PTEN_C2

PTEN_C2: pfam10409 (567 - 705)

PHA03307

PHA03307: cl33723 (818 - 1137)

DnaJ

DnaJ: cd06257 (1252 - 1297)

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  • 1305 a.a.
蛋白主名 其他名称

cyclin-G-associated kinase

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gak NCBI NCBI:2580
Macaca fascicularis Gak NCBI NCBI:102115623
Mus musculus Gak NCBI NCBI:231580