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BMT-090605 

目录号: HY-101290
产品使用指南

BMT-090605 是一种有效的选择性 AAK1 抑制剂,IC50 为 0.6 nM。BMT-090605 显示抗伤害活性。BMT-090605 抑制 BMP-2 诱导蛋白激酶 (BIKE) 和细胞周期蛋白 G 相关激酶 GAK,IC50 分别为 45 和 60 nM。

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BMT-090605 Chemical Structure

BMT-090605 Chemical Structure

CAS No. : 1551403-51-0

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  • 参考文献

生物活性

BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1].

体外研究
(In Vitro)

BMT-090605 shows a cellular IC50 of 0.63 ±0.39 nM for AAK1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

BMT-090605 (0.3-3 µg/rat; intrathecally at lumbar level L5/L6) causes antinociception by inhibiting AAK1 in the spinal cord[1].
The high dose of BMT-090605 (3 µg/rat) showed efficacy comparable to intrathecal clonidine (3 µg/rat). Exposure measurements from this study indicated that brain and plasma levels of BMT-090605 were <4 nM, whereas measurable levels (90–317 nM) were observed in lumbar spinal cord[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (chronic constriction injury (CCI) model)[1]
Dosage: 0.3-3 µg/rat
Administration: Intrathecally at lumbar level L5/L6
Result: Caused a dose-dependent reduction in thermal hyperalgesia.
分子量

364.44

Formula

C21H24N4O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
BMT-090605
目录号:
HY-101290
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