2. Gene
  3. Nefl - neurofilament light chain Gene

Nefl - neurofilament light chain Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Nfl; NF-L; NF68

基因 ID: 83613 | 基因类型: protein coding

关于 Nefl

功能概要

Enables Phospholipase binding activity and protein domain specific binding activity. Involved in several processes, including central nervous system development; intermediate filament Cytoskeleton organization; and response to corticosterone. Located in growth cone and neurofilament. Colocalizes with neuron projection. Used to study congenital hypothyroidism. Biomarker of hypothyroidism; mental depression; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); amyotrophic lateral sclerosis; and invasive ductal carcinoma. Orthologous to human NEFL (neurofilament light chain). [provided by Alliance of Genome Resources, Apr 2022]

Nefl 基因产物(1)

mRNA Protein Name
NM_031783.2 NP_113971.1 neurofilament light polypeptide
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phospholipase binding IPI
IPI: 通过物理相互作用推断
16819285 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
16819285 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
9388258 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
10439464 RGD
involved in hippocampus development IEP
IEP: 通过表达模式推断
14620872 RGD
involved in intermediate filament polymerization or depolymerization IDA
IDA: 通过直接分析推断
10362553 RGD
involved in neurofilament bundle assembly IDA
IDA: 通过直接分析推断
7721944 RGD
involved in protein polymerization IDA
IDA: 通过直接分析推断
17157386 RGD
involved in response to acrylamide IEP
IEP: 通过表达模式推断
17043767 RGD
involved in response to corticosterone IEP
IEP: 通过表达模式推断
17229084 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
18157692 RGD
involved in response to sodium arsenite IDA
IDA: 通过直接分析推断
18674524 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
18001836 RGD
involved in spinal cord development IEP
IEP: 通过表达模式推断
2108255 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
8737171 RGD
located in growth cone IDA
IDA: 通过直接分析推断
12226091 RGD
located in neurofilament IDA
IDA: 通过直接分析推断
7721944 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neurofilament light polypeptide

68 kDa neurofilament protein

68kDa neurofilament

neurofilament triplet L protein

neurofilament, light polypeptide

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09184 NEFL Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS17540 Nefl Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS23998 Nefl Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nefl NCBI NCBI:4747
Mus musculus Nefl NCBI NCBI:18039
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