1. Gene
  2. PLA2G10 - phospholipase A2 group X Gene

PLA2G10 - phospholipase A2 group X Gene

中文名称:磷脂酶 A2 X 组

种属: Homo sapiens

同用名: SPLA2; GXPLA2; GXSPLA2; sPLA2-X

基因 ID: 8399 | 基因类型: protein coding

关于 PLA2G10

Cytogenetic location: 16p13.12-p13.11 Genomic coordinates (GRCh38): 16:14,672,548-14,701,850 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 225 orthologues and 8 paralogues. Biased expression in stomach (RPKM 10.4), colon (RPKM 7.1) and 6 other tissues.

功能概要

该基因编码磷脂酶 A2 蛋白家族的成员。可变剪接导致多个转录本变体,其中至少一个编码前原蛋白,该前原蛋白经过蛋白水解处理以产生成熟酶。这种钙依赖性酶可水解甘油磷脂,产生游离脂肪酸和溶血磷脂。在一个例子中,这种酶催化花生四烯酸从细胞膜磷脂中释放,从而在各种炎症脂质介质 (如前列腺素) 的产生中发挥作用。编码的蛋白质可能通过其在脂质代谢中的作用促进乳腺癌细胞的存活。[RefSeq 提供,2015 年 11 月]

This gene encodes a member of the Phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature Enzyme. This calcium-dependent Enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this Enzyme catalyzes the release of arachidonic acid from cell membrane Phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast Cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]

PLA2G10 基因产物(1)

mRNA Protein Name
NM_003561.3 NP_003552.1 group 10 secretory phospholipase A2 preproprotein

PLA2G10 蛋白结构

Phospholip_A2_1

Phospholip_A2_1: Phospholipase A2 (55 - 151)

  • 0
  • 100
  • 165 a.a.
蛋白主名 其他名称

group 10 secretory phospholipase A2

group X secretory phospholipase A2

关联疾病

疾病名称 别名
Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced

Parkinson Disease 14, Autosomal Recessive

PARK14

Dystonia-Parkinsonism, Adult-Onset

Autosomal Recessive Parkinson Disease 14

Parkinson'S Disease 14

Dystonia-Parkinsonism Adult-Onset

Adult-Onset Dystonia-Parkinsonism

Dystonia-Parkinsonism, Paisan-Ruiz Type

Pla2g6-Related Dystonia-Parkinsonism

Parkinson Disease 14

Autosomal Recessive Parkinson'S Disease 14

Nbia/Dyt/Park-Pla2g6

Dystonia-Parkinsonism Paisan-Ruiz Type

Parkinson Disease 14 Autosomal Recessive

Parkinson Disease, Type 14

Meconium Aspiration Syndrome

Neonatal Aspiration Of Meconium

Meconium Aspiration

Mas

Meconium Aspiration Syndrome Of Newborn

Meconium Inhalation

Mas - [Meconium Aspiration Syndrome]

Meconium Aspiration Nos

Meconium Aspiration Syndrome Nos

Meconium Pneumonitis

Meconium Stained Liqueur Aspiration

Acute Chest Syndrome

Acute Chest Syndrome In Sickle Cell Disease

Inhalation Anthrax

Pulmonary Anthrax

Respiratory Anthrax

Inhalational Anthrax

Wool-Sorters' Disease

Woolsorters' Disease

Inhalation Anthrax Disease

Respiratory Anthrax Disease

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PLA2G10 RGD RGD:61935
Canis familiaris PLA2G10 VGNC VGNC:54056
Mus musculus PLA2G10 MGD MGI:1347522
Felis catus PLA2G10 VGNC VGNC:68878