2. Gene
  3. PARG - poly(ADP-ribose) glycohydrolase Gene

PARG - poly(ADP-ribose) glycohydrolase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 糖水解酶

种属: Homo sapiens

同用名: PARG99

基因 ID: 8505 | 基因类型: protein coding

关于 PARG

Cytogenetic location: 10q11.23 Genomic coordinates (GRCh38): 10:49,818,279-49,942,027 (from NCBI)

This gene has 7 transcripts (splice variants) and 245 orthologues. Ubiquitous expression in kidney (RPKM 6.5), testis (RPKM 6.1) and 25 other tissues.

功能概要

聚 (ADP-核糖) 糖水解酶 (PARG) 是负责聚 (ADP-核糖) 分解代谢的主要酶，聚 (ADP-核糖) 是染色体蛋白的可逆共价修饰剂。该蛋白质存在于许多组织中，可能会发生蛋白水解，产生更小的活性产物。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 1 月]

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

PARG 基因产物(15)

mRNA Protein Name
XR_007062014.1
XM_047425921.1 XP_047281877.1 poly(ADP-ribose) glycohydrolase isoform X2
NR_136756.3
NM_001324381.3 NP_001311310.1 poly(ADP-ribose) glycohydrolase isoform b
NM_001303486.3 NP_001290415.1 poly(ADP-ribose) glycohydrolase isoform b
NM_001303487.3 NP_001290416.1 poly(ADP-ribose) glycohydrolase isoform c
NR_130169.3
NR_130168.3
NM_001303489.3 NP_001290418.1 poly(ADP-ribose) glycohydrolase isoform d
NR_136755.3
NM_003631.5 NP_003622.2 poly(ADP-ribose) glycohydrolase isoform a
XM_011540305.2 XP_011538607.1 poly(ADP-ribose) glycohydrolase isoform X1
NR_136752.3
NR_136753.3
NR_136754.3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables poly(ADP-ribose) glycohydrolase activity IDA
IDA: 通过直接分析推断
9074616 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
27257257 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ATP generation from poly-ADP-D-ribose IDA
IDA: 通过直接分析推断
27257257 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
9074616 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PARG 蛋白结构

PARG_cat

PARG_cat: Poly (ADP-ribose) glycohydrolase (PARG) (93 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
蛋白主名 其他名称

poly(ADP-ribose) glycohydrolase

mitochondrial poly(ADP-ribose) glycohydrolase

关联疾病

疾病名称 别名
Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

CONDSIAS

Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures
Osebold-Remondini Syndrome

Brachydactyly Type A6

Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

Bda6

Brachydactyly, Type A6
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0889 Ethacridine lactate monohydrate Inhibitor 99.85% 否
HY-B2174 Ethacridine lactate Inhibitor 99.83% 否
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99965 Crovalimab Inhibitor ≥99.0% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-156881 PARG-IN-4 98.86% Phase 4
Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108360 PDD 00017273 99.06% 否
HY-128760 COH34 99.92% 否
HY-146248B TFMU-ADPr diammonium 98.78% 否
HY-133531 PDD00017272 99.47% 否
HY-137924 JA2131 Inhibitor 99.7% 否
HY-133530 PDD00017238 98.71% 否
HY-135846 PDD00031705 99.47% 否
HY-115666 COH34 analog 1 98.75% 否
HY-134354A pNP-ADPr disodium 99.93% 否
HY-146248A TFMU-ADPr triethylamine 97.26% 否
HY-134354 pNP-ADPr / 否
HY-146248 TFMU-ADPr / 否
HY-153574 BI01826025 Degrader / 否
HY-174242 PARG-IN-6 Inhibitor / 否
HY-RS10040 PARG Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS10041 Parg Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS10042 Parg Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-122041 Ethacridine / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PARG MGD MGI:1347094
Rattus norvegicus PARG RGD RGD:620387
Macaca mulatta PARG VGNC VGNC:106084
Canis familiaris PARG VGNC VGNC:53006
Others PARG NCBI
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