2. Gene
  3. DDO - D-aspartate oxidase Gene

DDO - D-aspartate oxidase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：D-天冬氨酸氧化酶

种属: Homo sapiens

同用名: DASOX; DASPO; DDO-1; DDO-2

基因 ID: 8528 | 基因类型: protein coding

关于 DDO

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,388,321-110,415,575 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues and 1 paralogue. Broad expression in heart (RPKM 7.9), kidney (RPKM 5.9) and 20 other tissues.

功能概要

该基因编码的蛋白质是一种过氧化物酶体黄素蛋白，可催化 D-天冬氨酸和 N-甲基 D-天冬氨酸的氧化脱氨作用。黄素腺嘌呤二核苷酸或 6-羟基黄素腺嘌呤二核苷酸可作为该反应的辅助因子。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2019 年 1 月]

The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2019]

DDO 基因产物(8)

mRNA Protein Name
NM_001368170.1 NP_001355099.1 D-aspartate oxidase isoform c
NM_001368171.1 NP_001355100.1 D-aspartate oxidase isoform d
NM_001368172.1 NP_001355101.1 D-aspartate oxidase isoform e
NM_001368173.1 NP_001355102.1 D-aspartate oxidase isoform f
NM_001368174.1 NP_001355103.1 D-aspartate oxidase isoform g
NM_001368175.1 NP_001355104.1 D-aspartate oxidase isoform g
NM_001372108.2 NP_001359037.1 D-aspartate oxidase isoform h
NM_004032.3 NP_004023.3 D-aspartate oxidase isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D-aspartate oxidase activity IDA
IDA: 通过直接分析推断
9163533 GOA
enables FAD binding IDA
IDA: 通过直接分析推断
20603179 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9820813 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in D-amino acid catabolic process IDA
IDA: 通过直接分析推断
20603179 GOA
involved in aspartate catabolic process IDA
IDA: 通过直接分析推断
9163533 GOA
involved in nervous system process IMP
IMP: 通过突变表型推断
28560262 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
37805834 GOA
is active in peroxisome IDA
IDA: 通过直接分析推断
37805834 GOA
located in peroxisome IDA
IDA: 通过直接分析推断
1991137 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DDO 蛋白结构

DAO

DAO: FAD dependent oxidoreductase (34 - 350)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
蛋白主名 其他名称

D-aspartate oxidase

D-aspartate oxidase, DDO

关联疾病

疾病名称 别名
Blackwater Fever

Black Water Fever

Hemoglobinuric, Malaria

Malarial Hemoglobinuria
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (21)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-155489 DDO-2728 98.55% 否
HY-139301 DDO-5936 Inhibitor 99.20% 否
HY-144634 DDO-7263 Activator 99.83% 否
HY-132233A DDO-2093 dihydrochloride Inhibitor 98.52% 否
HY-153331 DDO-2213 Inhibitor 98.84% 否
HY-132233 DDO-2093 Inhibitor / 否
HY-169947 DDO-6079 Inhibitor / 否
HY-144801A DDO-02005 Inhibitor / 否
HY-144801 DDO-02005 free base Inhibitor / 否
HY-144802 DDO-02001 Inhibitor / 否
HY-149863 DDO-8926 Inhibitor / 否
HY-152247 DDO3711 Inhibitor / 否
HY-169013 DDO-3733 Activator / 否
HY-170668 DDO-02267 Inhibitor / 否
HY-170915 DDO-3055 Inhibitor / 否
HY-172210 DDO-8958 Inducer / 否
HY-175247 DDO-4033 Agonist / 否
HY-176404 DDO-6691 Inhibitor / 否
HY-RS03618 DDO Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19106 Ddo Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25596 Ddo Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DDO RGD RGD:1595123
Felis catus DDO VGNC VGNC:61393
Bos taurus DDO VGNC VGNC:27951
Macaca mulatta DDO VGNC VGNC:104372
Mus musculus DDO MGD MGI:1925528
Canis familiaris DDO VGNC VGNC:39840
Others DDO NCBI
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