2. Epigenetics
  3. Histone Methyltransferase
  4. DDO-2093

DDO-2093 是一种有效的 MLL1 和 WDR5 蛋白-蛋白相互作用抑制剂 (IC50=8.6 nM; Kd=11.6 nM)，具有抗肿瘤活性。DDO-2093 选择性抑制 MLL 复合物的催化活性。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 DDO-2093 dihydrochloride 通常具有更好的水溶性和稳定性。

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DDO-2093 Chemical Structure

DDO-2093 Chemical Structure

CAS No. : 2250024-74-7

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DDO-2093 的其他形式现货产品:

Customer Review

Other Forms of DDO-2093:

DDO-2093 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DDO-2093 is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 selectively inhibits the catalytic activity of MLL complex[1].

体外研究
(In Vitro)

DDO-2093 (5 μM; pretreated 7 days) inhibits MLL-fusion protein dependent genes expression (HOXA9 and Meis1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DDO-2093 相关抗体:

Western Blot Analysis[1]

Cell Line: MV4-11 cells
Concentration: 1, 2.5, 5, and 10 μM
Incubation Time: 7 days
Result: Dose-dependently reduced the mono-, di-, and trimethylation of H3K4.
体内研究
(In Vivo)

DDO-2093 (20-80 mg/kg; i.p.; every other day for 21 days) significantly suppresses the tumor size and weight in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (MV4-11 human leukemia cancer xenografts)[1]
Dosage: 20 mg/kg, 40 mg/kg and 80 mg/kg
Administration: Intraperitoneal injection; every other day for 21 days
Result: Had the tumor volume growth inhibition (GI) values were calculated to be 13.7%, 37.6% and 63.9% with doses of 20 mg/kg, 40 mg/kg and 80 mg/kg, respectively.
分子量

614.11

Formula

C29H37ClFN9O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DDO-2093 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-20932250024-74-7DDO2093DDO 2093Histone MethyltransferaseMLL1WDR5antitumorcatalyticcomplexMV4-11leukemiacancerInhibitorinhibitorinhibit

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DDO-2093
目录号：
HY-132233
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