2. Gene
  3. MCU - mitochondrial calcium uniporter Gene

MCU - mitochondrial calcium uniporter Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：线粒体钙单向转运体

种属: Homo sapiens

同用名: HsMCU; C10orf42; CCDC109A

基因 ID: 90550 | 基因类型: protein coding

关于 MCU

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,692,143-72,887,694 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in stomach (RPKM 19.3), colon (RPKM 14.7) and 24 other tissues.

功能概要

该基因编码定位于线粒体内膜的钙转运蛋白。编码的蛋白质与线粒体钙摄取 1 相互作用。可变剪接导致多个转录变体。[RefSeq 提供，2012 年 7 月]

This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

MCU 基因产物(3)

mRNA Protein Name
NM_001270679.2 NP_001257608.1 calcium uniporter protein, mitochondrial isoform 2 precursor
NM_001270680.3 NP_001257609.1 calcium uniporter protein, mitochondrial isoform 3
NM_138357.3 NP_612366.1 calcium uniporter protein, mitochondrial isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium channel activity IDA
IDA: 通过直接分析推断
21685888 GOA
enables calcium channel activity IMP
IMP: 通过突变表型推断
23755363 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21685886 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21685886 GOA
enables uniporter activity IDA
IDA: 通过直接分析推断
21685886 GOA
enables uniporter activity IMP
IMP: 通过突变表型推断
23755363 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium import into the mitochondrion IDA
IDA: 通过直接分析推断
22925203 GOA
involved in calcium import into the mitochondrion IMP
IMP: 通过突变表型推断
23755363 GOA
involved in calcium-mediated signaling IDA
IDA: 通过直接分析推断
21685886 GOA
involved in cellular response to calcium ion starvation IMP
IMP: 通过突变表型推断
32494073 GOA
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
22829870 GOA
involved in mitochondrial calcium ion homeostasis IDA
IDA: 通过直接分析推断
32494073 GOA
involved in mitochondrial calcium ion transmembrane transport IDA
IDA: 通过直接分析推断
21685888 GOA
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
21685886 GOA
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
22829870 GOA
involved in positive regulation of mitochondrial calcium ion concentration IDA
IDA: 通过直接分析推断
21685888 GOA
involved in positive regulation of mitochondrial calcium ion concentration IMP
IMP: 通过突变表型推断
21685886 GOA
involved in positive regulation of mitochondrial fission IMP
IMP: 通过突变表型推断
28388446 GOA
involved in positive regulation of neutrophil chemotaxis IMP
IMP: 通过突变表型推断
28388446 GOA
involved in protein complex oligomerization IDA
IDA: 通过直接分析推断
21685886 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calcium channel complex IDA
IDA: 通过直接分析推断
23755363 GOA
is active in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
31080062 GOA
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
21685886 GOA
part of uniplex complex IDA
IDA: 通过直接分析推断
24231807 GOA
part of uniplex complex IPI
IPI: 通过物理相互作用推断
32494073 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MCU 蛋白结构

MCU

MCU: Mitochondrial calcium uniporter (109 - 321)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
蛋白主名 其他名称

calcium uniporter protein, mitochondrial

coiled-coil domain-containing protein 109A

MCU 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MCU Q8NE86 SMDT1 Homo sapiens Q9H4I9
Anti Tag CoIP
32494073
种属内
MCU Q8NE86 MICU1 Homo sapiens Q9BPX6
Anti Tag CoIP
26387864
种属内
MCU Q8NE86 MICU1 Homo sapiens Q9BPX6
IF
26387864
种属内
MCU Q8NE86 MICU1 Homo sapiens Q9BPX6
Anti Tag CoIP
32494073
种属间: 跨种属相互作用 种属内: 同种属相互作用

MCU 抗体

目录号 产品名 应用 反应物种
HY-P80216 MCU Antibody (YA704) WB, FC Human

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Ischemia

Acute Coronary Syndrome
Myopathy With Extrapyramidal Signs

Proximal Myopathy With Extrapyramidal Signs

MPXPS

Myopathy, With Extrapyramidal Signs
Ovarian Endometrial Cancer

Endometrioid Neoplasm Of Ovary

Malignant Ovarian Endometrioid Tumor

Ovarian Endometrioid Neoplasm
Spinocerebellar Ataxia 28

Spinocerebellar Ataxia Type 28

SCA28

Ataxia, Spinocerebellar, Type 28
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-138620 MCU-i4 Inhibitor 99.87% 否
HY-W194810 MCU-i11 98.42% 否
HY-117548 UNC1062 98.92% 否
HY-RS08252 MCU Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16775 Mcu Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23215 Mcu Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MCU VGNC VGNC:63421
Rattus norvegicus MCU RGD RGD:1589771
Mus musculus MCU MGD MGI:3026965
Macaca mulatta MCU VGNC VGNC:74560
Canis familiaris MCU VGNC VGNC:43096
Bos taurus MCU VGNC VGNC:31325
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