2. Gene
  3. ONECUT2 - one cut homeobox 2 Gene

ONECUT2 - one cut homeobox 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：一切同源盒 2

种属: Homo sapiens

同用名: OC2; OC-2

基因 ID: 9480 | 基因类型: protein coding

关于 ONECUT2

Cytogenetic location: 18q21.31 Genomic coordinates (GRCh38): 18:57,435,374-57,491,298 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues and 2 paralogues. Biased expression in gall bladder (RPKM 4.8), duodenum (RPKM 3.7) and 2 other tissues.

功能概要

该基因编码 onecut 转录因子家族的一个成员，其特征是一个剪切域和一个非典型的同源域。该蛋白质与特定的 DNA 序列结合并刺激靶基因的表达，包括参与黑素细胞和肝细胞分化的基因。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]

ONECUT2 基因产物(1)

mRNA Protein Name
NM_004852.3 NP_004843.2 one cut domain family member 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11478782 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11478782 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11478782 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ONECUT2 蛋白结构

CUT

CUT: CUT domain (328 - 406)

Homeobox

Homeobox: Homeobox domain (427 - 480)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
蛋白主名 其他名称

one cut domain family member 2

HNF-6-beta

关联疾病

疾病名称 别名
Ureter, Cancer Of

Ureter Carcinoma

Ureter Cancer

Ureteral Neoplasms

Malignant Neoplasm Of Ureter

Malignant Tumour Of Ureter

Malignant Ureteral Tumor

Ureteral Carcinoma

Ureteral Neoplasm
Osteogenesis Imperfecta, Type Xvi

Osteogenesis Imperfecta Type 16

OI16

Oi, Type Xvi

Osteogenesis Imperfecta Type Xvi

Chromosome 11p11.2 Deletion Syndrome 91.3-Kb

Osteogenesis Imperfecta 16

Chromosome 11p11.2 Deletion Syndrome, 91.3-Kb
Hemophilia B

Christmas Disease

Factor Ix Deficiency

F9 Deficiency

HEMB

Plasma Thromboplastin Component Deficiency

Congenital Factor Ix Deficiency

Mild Hemophilia B

Severe Hemophilia B

Congenital Factor Ix Disorder

Deficiency, Functional Factor Ix

Hem B

Mild Congenital F9 Deficiency

Mild Congenital Factor Ix Deficiency

Moderate Hemophilia B

Moderate Congenital F9 Deficiency

Moderate Congenital Factor Ix Deficiency

Severe Congenital F9 Deficiency

Severe Congenital Factor Ix Deficiency

Bleeding Disorder In Hemophilia B Carriers

Congenital F9 Deficiency

Recessive X-Linked Hemophilia B
Osteogenesis Imperfecta, Type Ii

Vrolik Type Of Osteogenesis Imperfecta

Osteogenesis Imperfecta Type 2

OI2

Oi, Type Ii

Osteogenesis Imperfecta Congenita

Oic

Osteogenesis Imperfecta Type Ii

Lethal Osteogenesis Imperfecta

Oi Type 2

Osteogenesis Imperfecta Congenita Perinatal Lethal Form

Osteogenesis Imperfecta Congenita, Perinatal Lethal Form

Perinatal Lethal Osteogenesis Imperfecta Congenita

Perinatally Lethal Oi

Osteogenesis Imperfecta 2

Oi-Ii

Oi-Iia

Oi Type Iia

Osteogenesis Imperfecta Type Iia

Osteogenesis Imperfecta Type Ii Autosomal Dominant

Oi Type Ii

Osteogenesis Imperfecta, Dominant Perinatal Lethal
Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122611A CSRM617 hydrochloride 99.97% 否
HY-122611 CSRM617 / 否
HY-RS09786 ONECUT2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19546 Onecut2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26042 Onecut2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ONECUT2 VGNC VGNC:53747
Mus musculus ONECUT2 MGD MGI:1891408
Macaca mulatta ONECUT2 VGNC VGNC:75585
Felis catus ONECUT2 VGNC VGNC:68627
Rattus norvegicus ONECUT2 RGD RGD:1564677
Bos taurus ONECUT2 VGNC VGNC:56369
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