1. Vitamin D Related/Nuclear Receptor Apoptosis
  2. Androgen Receptor Apoptosis
  3. CSRM617 hydrochloride

CSRM617 hydrochloride 

目录号: HY-122611A 纯度: 99.97%
COA 产品使用指南

CSRM617 hydrochloride 是转录因子 ONECUT2 (OC2,雄激素受体 AR 的主要调节剂) 的选择性小分子抑制剂,在 SPR 测定中 Kd 为 7.43 uM,直接与 OC2-HOX 结构域结合。CSRM617 hydrochloride 通过切割 Caspase-3PARP 诱导细胞凋亡 (apoptosis)。CSRM617 hydrochloride 在小鼠的前列腺癌模型中耐受性良好。

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CSRM617 hydrochloride Chemical Structure

CSRM617 hydrochloride Chemical Structure

CAS No. : 1353749-74-2

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1 mg ¥320
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5 mg ¥720
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10 mg ¥1050
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25 mg ¥1800
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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model[1]

体外研究
(In Vitro)

CSRM617 (0.01-100 μM; 48 hours) hydrochloride inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells[1].
CSRM617 (10-20 μM; 48 hours) hydrochloride induces apoptosis in 22Rv1 cells results in cell death in a concentration-dependent fashion[1].
CSRM617 (20 μM; 72 hours) hydrochloride induces apoptosis in 22Rv1 cells by appearance of cleaved Caspase-3 and PARP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

CSRM617 (50 mg/kg; p.o.; daily, for 20 d) inhibits tumor growth in SCID mice with 22Rv1 xenograft[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice with 22Rv1 xenograft[1]
Dosage: 50 mg/kg
Administration: Oral administration; daily, for 20 days
Result: Elicited a significant reduction in the onset and growth of diffuse metastases.
分子量

291.69

Formula

C10H14ClN3O5

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (428.54 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4283 mL 17.1415 mL 34.2830 mL
5 mM 0.6857 mL 3.4283 mL 6.8566 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4283 mL 17.1415 mL 34.2830 mL 85.7074 mL
5 mM 0.6857 mL 3.4283 mL 6.8566 mL 17.1415 mL
10 mM 0.3428 mL 1.7141 mL 3.4283 mL 8.5707 mL
15 mM 0.2286 mL 1.1428 mL 2.2855 mL 5.7138 mL
20 mM 0.1714 mL 0.8571 mL 1.7141 mL 4.2854 mL
25 mM 0.1371 mL 0.6857 mL 1.3713 mL 3.4283 mL
30 mM 0.1143 mL 0.5714 mL 1.1428 mL 2.8569 mL
40 mM 0.0857 mL 0.4285 mL 0.8571 mL 2.1427 mL
50 mM 0.0686 mL 0.3428 mL 0.6857 mL 1.7141 mL
60 mM 0.0571 mL 0.2857 mL 0.5714 mL 1.4285 mL
80 mM 0.0429 mL 0.2143 mL 0.4285 mL 1.0713 mL
100 mM 0.0343 mL 0.1714 mL 0.3428 mL 0.8571 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
CSRM617 hydrochloride
目录号:
HY-122611A
需求量: