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CSRM617 

目录号: HY-122611
产品使用指南

CSRM617 是转录因子 ONECUT2 (OC2) 的小分子抑制剂,在 SPR 测定中 Kd 为7.43 uM,直接与 OC2-HOX 结构域结合。CSRM617 通过切割 Caspase-3 和 PARP 诱导细胞凋亡。

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CSRM617 Chemical Structure

CSRM617 Chemical Structure

CAS No. : 787504-88-5

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Description

CSRM617 is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP[1].

In Vitro

CSRM617 (0.01-100 μM; 48 hours) inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells[1].
CSRM617 (10-20 μM; 48 hours) induces apoptosis in 22Rv1 cells results in cell death in a concentration-dependent fashion[1].
CSRM617 (20 μM; 72 hours) induces apoptosis in 22Rv1 cells by appearance of cleaved Caspase-3 and PARP[1].

Molecular Weight

255.23

Formula

C₁₀H₁₃N₃O₅

CAS No.

787504-88-5

SMILES

N[C@@H](CO)C(N/N=C/C1=CC=C(O)C(O)=C1O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
CSRM617
目录号:
HY-122611
需求量:

CSRM617

Cat. No.: HY-122611