GPRASP1 - G protein-coupled receptor associated sorting protein 1 Gene

中文名称：G 蛋白偶联受体相关分选蛋白 1

种属: Homo sapiens

同用名: GASP; GASP1; GASP-1

关于 GPRASP1

功能概要

该基因编码 GPRASP (G 蛋白偶联受体相关分选蛋白) 家族的成员。该蛋白质可调节溶酶体分选和多种 G 蛋白偶联受体的功能下调。它靶向溶酶体中降解的受体。与这种分选蛋白相互作用的受体包括 D2 多巴胺受体 (DRD2) 、δ 阿片受体 (OPRD1) 、β2 肾上腺素能受体 (ADRB2) 、D4 多巴胺受体 (DRD4) 和大麻素 1 受体 (CB1R) 。已经鉴定出编码相同蛋白质的多个选择性剪接的转录物变体。[RefSeq 提供，2010 年 5 月]

This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 Dopamine Receptor (DRD2), delta Opioid Receptor (OPRD1), beta-2 Adrenergic Receptor (ADRB2), D4 Dopamine Receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]