2. Gene
  3. ADGRE5 - adhesion G protein-coupled receptor E5 Gene

ADGRE5 - adhesion G protein-coupled receptor E5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：粘附 G 蛋白偶联受体 E5

种属: Homo sapiens

同用名: CD97; TM7LN1

基因 ID: 976 | 基因类型: protein coding

关于 ADGRE5

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,381,144-14,408,725 (from NCBI)

This gene has 16 transcripts (splice variants), 204 orthologues and 42 paralogues. Broad expression in bone marrow (RPKM 63.9), spleen (RPKM 54.1) and 23 other tissues.

功能概要

该基因编码粘附 G 蛋白偶联受体的 EGF-TM7 亚家族成员，该受体介导细胞间相互作用。这些蛋白质通过自催化蛋白水解被切割成大的细胞外亚基和七跨膜亚基，它们作为受体复合物结合在细胞表面。编码的蛋白质可能在细胞粘附以及白细胞募集、激活和迁移中发挥作用，并包含多个细胞外 EGF 样重复序列，这些重复序列介导与硫酸软骨素和细胞表面补体调节蛋白 CD55 的结合。该基因的表达可能在几种癌症的进展中发挥作用。已经对该基因观察到编码具有 3 至 5 个 EGF 样重复的多个亚型的可变剪接转录物变体。该基因与其他 EGF-TM7 基因位于 19 号染色体短臂上的一个簇中。[RefSeq 提供，2011 年 6 月]

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of Cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

ADGRE5 基因产物(3)

mRNA Protein Name
NM_001025160.3 NP_001020331.1 adhesion G protein-coupled receptor E5 isoform 3 preproprotein
NM_001784.5 NP_001775.2 adhesion G protein-coupled receptor E5 isoform 2 preproprotein
NM_078481.4 NP_510966.1 adhesion G protein-coupled receptor E5 isoform 1 preproprotein

ADGRE5 蛋白结构

EGF_CA

EGF_CA: Calcium-binding EGF domain (64 - 114)

EGF_CA

EGF_CA: Calcium-binding EGF domain (116 - 158)

EGF_CA

EGF_CA: Calcium-binding EGF domain (160 - 207)

EGF_CA

EGF_CA: Calcium-binding EGF domain (209 - 256)

GPS

GPS: GPCR proteolysis site, GPS, motif (493 - 537)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (546 - 781)

  • 0
  • 200
  • 400
  • 600
  • 835 a.a.
蛋白主名 其他名称

adhesion G protein-coupled receptor E5

CD97 molecule

重组 ADGRE5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75369 CD97 Protein, Human (HEK293, His) P48960-2/NP_001775.2 (Q21-Q398) ≥95%
HY-P75370 CD97 Protein, Human (HEK293, hFc) P48960/NP_001775 (Q21-Q398) ≥95%

关联疾病

疾病名称 别名
Vibratory Urticaria

Vibratory Angioedema

Dermodistortive Urticaria

VBU

Ddu

Angioedema, Vibratory
Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma

Anaplastic Thyroid Cancer

Thyroid Cancer, Anaplastic

Thyroid Carcinoma, Anaplastic

Thyroid Carcinoma Anaplastic
Reactive Arthritis

Postdysenteric Arthropathy

Reiter Disease

Pira

Reiter Syndrome

Reiters Syndrome

Arthritis, Reactive

Fiessinger Leroy Reiter Syndrome

Post-Bacterial Arthropathy

Reiter'S Disease

Post-Infectious Arthritis

Post-Infectious Reactive Arthropathy

Reiter'S Syndrome

Arthritis Urethritica

Fiessinger-Leroy Disease

Polyarthritis Enterica

Venereal Arthritis

Arthritis Reactive

Post-Dysenteric Arthropathy

Arthritis, Venereal
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Physical Urticaria

Symptomatic Dermographism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00351 ADGRE5 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ADGRE5 MGD MGI:1347095
Macaca mulatta ADGRE5 VGNC VGNC:69441
Canis familiaris ADGRE5 VGNC VGNC:37637
Felis catus ADGRE5 VGNC VGNC:82335
Rattus norvegicus ADGRE5 RGD RGD:1305595
Bos taurus ADGRE5 VGNC VGNC:55196
Others ADGRE5 NCBI
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