2. Academic Validation
  3. Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L

Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L

  • J Ethnopharmacol. 2004 Dec;95(2-3):455-7. doi: 10.1016/j.jep.2004.06.031.
Theodore A Bischoff 1,  Charles J Kelley,  Yvette Karchesy,  Maria Laurantos,  Phuc Nguyen-Dinh,  Abdul Ghafoor Arefi
Affiliations

Affiliation

  • 1 Department of Pharmacy, Massachusetts General Hospital, Boston, MA 02114, USA. Bischoff.Theodore@MGH.Harvard.edu
PMID: 15507374 DOI: 10.1016/j.jep.2004.06.031
Abstract

Folklore reports from Afghanistan prior to the wars described the use of aqueous root extracts of Cichorium intybus (L.) as a light-sensitive plant remedy for malaria. Preparative isolation and bioassay against HB3 clone of strain Honduras-1 of Plasmodium falciparum identified the previously known light-sensitive sesquiterpene lactones Lactucin and Lactucopicrin to be antimalarial compounds.

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