1. Academic Validation
  2. Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin

Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin

  • Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:105-6. doi: 10.1590/s0074-02762005000900017.
Camila Squarzoni Dale 1 Rosana de Lima Pagano Vanessa Rioli
Affiliations

Affiliation

  • 1 Laboratório de Fisiopatologia, Instituto Butantan, São Paulo, SP 05503-900, Brasil. camisdale@butantan.gov.br
Abstract

Hemopressin (PVNFKFLSH), a novel bioactive peptide derived from the alpha1-chain of hemoglobin, was originally isolated from rat brain homogenates. Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting Enzyme (ACE). Hemopressin also exerts an antinociceptive action in experimental inflammatory hyperalgesia induced by carrageenin or bradykinin via a mechanism that is independent of opioids. These findings suggest that this peptide may have important regulatory physiological actions in vivo.

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