1. Academic Validation
  2. Synthesis of deserpidine from reserpine

Synthesis of deserpidine from reserpine

  • J Nat Prod. 2005 Nov;68(11):1629-31. doi: 10.1021/np050179x.
Greta Varchi 1 Arturo Battaglia Cristian Samorì Eleonora Baldelli Bruno Danieli Gabriele Fontana Andrea Guerrini Ezio Bombardelli
Affiliations

Affiliation

  • 1 Istituto CNR per la Sintesi Organica e Fotoreattività ISOF, Area della Ricerca di Bologna, Via P., Gobetti 101, 40129 Bologna, Italy. G.Varchi@isof.cnr.it
Abstract

The Rauwolfia Alkaloids reserpine (1) and deserpidine (2), two Alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.

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