1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)

Angiotensin-converting Enzyme (ACE)

Angiotensin-converting enzyme (ACE) indirectly increases blood pressure by causing blood vessels to constrict. ACE does that by converting angiotensin I to angiotensin II, which constricts the vessels. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. It has two primary functions: ACE catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor in a substrate concentration-dependent manner. ACE degrades bradykinin, a potent vasodilator, and other vasoactive peptides. These two actions make ACE inhibition a goal in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, leading to systematic dilation of the arteries and veins and a decrease in arterial blood pressure.

Angiotensin-converting Enzyme (ACE) 相关产品 (42):

Cat. No. Product Name Effect Purity
  • HY-12403
    Angiotensin 1-7 Inhibitor 99.61%
    Angiotensin 1-7 (Ang-(1-7)) 是肾素-血管紧张素系统 (RAS) 的主要活性成分,由血管紧张素转换酶 2 (ACE2) 分解血管紧张素 II 产生。Angiotensin 1-7 抑制纯化的犬血管紧张素转换酶 (ACE) 活性,IC50 值为 0.65 μM。Angiotensin 1-7 通过抑制血管紧张素转换酶和释放一氧化氮,可作为激肽诱导的血管舒张的局部协同调节剂。Angiotensin 1-7 阻断 Ang II 诱导的平滑肌细胞增殖和肥大,并显示对内皮的抗血管生成和生长抑制作用。Angiotensin 1-7 显示出抗炎活性。
  • HY-B0368
    Captopril Inhibitor 98.05%
    Captopril (SQ-14534) 是血管紧张素转化酶(ACE)抑制剂。
  • HY-B0331A
    Enalapril maleate Inhibitor 99.96%
    Enalapril maleate (MK-421 maleate) 是 Enalapril 的活性代谢物,是血管紧张素转化酶(ACE)抑制剂。
  • HY-N2021A
    Phosphoramidon Disodium Inhibitor >98.0%
    Phosphoramidon Disodium 是金属蛋白酶 (metalloprotease) 抑制剂 。抑制内皮素转化酶 (ECE) ,中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50 值分别为 3.5 ,0.034 和 78 μM。
  • HY-B0130A
    Perindopril erbumine Inhibitor 99.33%
    Perindopril erbumine (Perindopril tert-butylamine salt) 是长效血管紧张素转换酶(ACE)抑制剂。
  • HY-106446
    Rentiapril Inhibitor 98.02%
    Rentiapril 是一种具有口服活性的血管紧张素转换酶 (ACE) 抑制剂,具有抗高血压活性。
  • HY-P0266A
    N-Acetyl-Ser-Asp-Lys-Pro TFA
    N-Acetyl-Ser-Asp-Lys-Pro (TFA) 是来自骨髓的内源性四肽,是 ACE 的N-末端位点的特异性底物。
  • HY-N2165
    Vicenin 2 Inhibitor
    Vicenin 2 来自广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂,IC50 为 43.83 μM。
  • HY-B0093A
    Benazepril hydrochloride Inhibitor 99.85%
    Benazepril盐酸盐是血管紧张素转化酶(ACE)抑制剂,可作用于高血压。
  • HY-B0382
    Fosinopril sodium Inhibitor >98.0%
    Fosinopril 钠是血管紧张素转换酶(ACE)抑制剂的原药,可作用于高血压和慢性心力衰竭。
  • HY-18206A
    Lisinopril dihydrate Inhibitor >98.0%
    Lisinopri (dihydrate) (lMK-521 (dihydrate)) 是血管紧张素转化酶抑制剂,可作用于高血压,充血性心力衰竭和心脏病等。
  • HY-B0384
    Temocapril hydrochloride Inhibitor 99.52%
    Temocapril 盐酸盐是长效血管紧张素转换酶(ACE)抑制剂,可作用于高血压。
  • HY-B0231
    Enalaprilat dihydrate Inhibitor >99.0%
    Enalaprilat (dihydrate) (MK-422) 是血管紧张素转化酶 (ACE) 抑制剂,IC50 为 1.94 nM。
  • HY-B0477
    Quinapril hydrochloride Inhibitor 99.10%
    Quinapril (hydrochloride) (CI-906) 是血管紧张素转化酶 (ACE) 抑制剂的原药。
  • HY-B0592
    Trandolapril Inhibitor 98.01%
    Trandolapril(RU44570)是ACE抑制剂,可作用于高血压。
  • HY-B0279
    Ramipril Inhibitor 99.81%
    Ramipril (HOE-498) 是ACE抑制剂,IC50为5 nM。
  • HY-A0043A
    Cilazapril monohydrate Inhibitor 98.63%
    Cilazapril一水合物是血管紧张素转化酶抑制剂,可作用于高血压和充血性心力衰竭。
  • HY-18208
    Omapatrilat Inhibitor
    Omapatrilat是金属蛋白酶ACENEP的双重抑制剂,Ki值分别为0.64和0.45 nM。
  • HY-B1451
    Imidapril hydrochloride Inhibitor 99.95%
    Imidapril hydrochloride (TA-6366) 是血管紧张素转换酶 (ACE) 抑制剂,具有抗高血压活性。
  • HY-B0378A
    Moexipril hydrochloride Inhibitor 98.49%
    Moexipril 盐酸盐是口服活性的不含巯基的血管紧张素转化酶抑制剂,可作用于高血压和充血性心力衰竭。
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