1. Academic Validation
  2. Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities

  • J Med Chem. 2006 May 4;49(9):2845-9. doi: 10.1021/jm0601856.
Christophe Biot 1 Wassim Daher Natascha Chavain Thierry Fandeur Jamal Khalife Daniel Dive Erik De Clercq
Affiliations

Affiliation

  • 1 Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108, 59652 Villeneuve d' Ascq Cedex, France. christophe.biot@ensc-lille.fr
Abstract

Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert Antiviral effects with some selectivity toward SARS-CoV Infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.

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