1. Academic Validation
  2. Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb

Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb

  • Nat Prod Res. 2007 May 20;21(6):487-93. doi: 10.1080/14786410601012265.
Sung-Gyu Choi 1 Jiin Kim Nack-Do Sung Kwang-Hee Son Hyae-Gyeong Cheon Kwang-Rok Kim Byoung-Mog Kwon
Affiliations

Affiliation

  • 1 Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, Yoosung-Gu, Daejeon, Republic of Korea.
Abstract

Three Anthraquinones, Cdc25B Phosphatase inhibitors, were isolated from the methanolic extract of the roots of Polygonum multiflorum Thunb. (Polygonaceae). Anthraquinones, physcion (1), emodin (2), and questin (3), inhibited the enzymatic activity of Cdc25B Phosphatase with IC(50) values of 62.5, 30, and 34 microg mL(-1), respectively. Emodin (2) and questin (3) strongly inhibited the growth of human colon Cancer cells, SW620 with GI(50) values of 6.1 and 0.9 microg mL(-1), respectively. Commercially available Anthraquinones, chrysophanol (4), and rhein (5) also inhibited Cdc25B Phosphatase with IC(50) values of 10.7 and 22.1 microg mL(-1), respectively.

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