1. Academic Validation
  2. Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials

Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials

  • Contact Dermatitis. 2012 Nov;67(5):284-92. doi: 10.1111/j.1600-0536.2012.02073.x.
Takahiro Doi 1 Akihiro Takeda Akiko Asada Keiji Kajimura
Affiliations

Affiliation

  • 1 Osaka Prefectural Institute of Public Health, Nakamichi, Higashinari-ku, Osaka, Japan. tdoi@iph.pref.osaka.jp
Abstract

Background: Imidazolidinyl urea releases formaldehyde through decomposition. However, there have been few reports on the chemistry of imidazolidinyl urea in cosmetics.

Objectives: The aim of this study was to characterize imidazolidinyl urea-derived compounds in cosmetics and to determine which compounds are responsible for the cross-reactivity with diazolidinyl urea.

Methods: We analysed imidazolidinyl urea dissolved in aqueous solutions, imidazolidinyl urea patch test Materials and imidazolidinyl urea-preserved cosmetics by high-performance liquid chromatography/photodiode array detection and liquid chromatography/mass spectrometry. The results were compared with those obtained with a diazolidinyl urea aqueous solution.

Results: In the analysed cosmetic samples and patch test Materials, imidazolidinyl urea was primarily composed of allantoin, (4-hydroxymethyl-2,5-dioxo-imidazolidine-4-yl)-urea (HU), (3,4-bis-hydroxymethyl-2,5-dioxo-imidazolidine-4-yl)-urea (3,4-BHU), and (3-hydroxymethyl-2,5-dioxo-imidazolidine-4-yl)-urea.

Conclusions: Two of the imidazolidinyl urea-derived major decomposition compounds - HU and 3,4-BHU - are common in the diazolidinyl urea-decomposed compound present in cosmetics. These compounds are possible causative agents of the cross-reactivity between diazolidinyl urea and imidazolidinyl urea.

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