1. Academic Validation
  2. Synthesis of the Pentacyclic Core of Citreamicin η

Synthesis of the Pentacyclic Core of Citreamicin η

  • Org Lett. 2017 Feb 17;19(4):790-793. doi: 10.1021/acs.orglett.6b03760.
Shawn Blumberg 1 Stephen F Martin 1
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Abstract

The citreamicins comprise a novel class of polycyclic xanthone natural products that have not yet yielded to total synthesis. A concise 11-step synthesis of the pentacyclic core of citreamicin η is now reported that features the use of a general approach for the synthesis of 1,4-dioxygenated Xanthones. The synthesis also showcases improved techniques for effecting regioselective bromination of certain substituted Phenols and coupling of acetylides with hindered ketones.

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