2. Academic Validation
  3. Bisphenol A affects trophoblast invasion by inhibiting CXCL8 expression in decidual stromal cells

Bisphenol A affects trophoblast invasion by inhibiting CXCL8 expression in decidual stromal cells

  • Mol Cell Endocrinol. 2018 Jul 15;470:38-47. doi: 10.1016/j.mce.2017.07.016.
Xiaoqian Li 1,  Yina Wang 2,  Pu Wei 1,  Dongyan Shi 2,  Shuang Wen 2,  Fengjiao Wu 2,  Lixin Liu 3,  Ninghe Ye 4,  Hong Zhou 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China.
  • 2 Department of Immunology, Nanjing Medical University, Nanjing, 211166, China.
  • 3 Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E5, Canada.
  • 4 Nanjing Maternity and Children Care Hospital, Nanjing, 210029, China.
  • 5 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China; Department of Immunology, Nanjing Medical University, Nanjing, 211166, China. Electronic address: hzhou@njmu.edu.cn.
PMID: 28736254 DOI: 10.1016/j.mce.2017.07.016
Abstract

Bisphenol A (BPA), an environmental endocrine-disrupting organic chemical, has been positively associated with the rate of implantation failure of in vitro fertilization. However, the underlying mechanisms remain unclear. To reveal the impact and the underlying mechanism of BPA on the crosstalk between trophoblast and decidual stromal cells (DSCs), we determined whether BPA was able to affect trophoblast invasion in vitro. We found that BPA significantly inhibited CXCL8 expression in DSCs, which hindered trophoblast invasion, and activated the phosphorylation of ERK in DSCs. U0126, an inhibitor of ERK activation, remarkably rescued trophoblast invasion and the inhibition of CXCL8 expression caused by BPA treatment. Moreover, the nuclear Estrogen receptor Antagonist ICI 182,780 and transmembrane G protein-coupled receptor GPR30 (membrane Estrogen Receptor) antagonist G15 significantly blocked the phosphorylation of ERK and reversed the reduction of trophoblast invasion. In brief, BPA activated ERK through nuclear and membrane estrogen receptors and inhibited CXCL8 expression in DSCs, thereby affecting their regulation of trophoblast invasion.

Keywords

Bisphenol A; CXCL8; Cell invasion; Decidual stromal cells; Trophoblast.

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