1. Academic Validation
  2. KLF15 suppresses cell growth and predicts prognosis in lung adenocarcinoma

KLF15 suppresses cell growth and predicts prognosis in lung adenocarcinoma

  • Biomed Pharmacother. 2018 Oct;106:672-677. doi: 10.1016/j.biopha.2018.07.006.
Xiaoyan Wang 1 Mingqing He 2 Jianzhong Li 2 Haiying Wang 3 Jianan Huang 4
Affiliations

Affiliations

  • 1 Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, PR China; Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, PR China.
  • 2 Department of Geriatrics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, PR China.
  • 3 Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, PR China.
  • 4 Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, PR China. Electronic address: lnyx01@163.com.
Abstract

Krüppel-like factors (KLFs) are transcription factors containing three different C2H2-type zinc finger domains in their carboxy-terminal regions which have been identified to play important roles in a variety of cancers. However, little is known about KLF15 in lung adenocarcinoma (LAUD). Our study demonstrated that the expression levels of KLF15 were observably down-regulated in LAUD tissues compared to paired adjacent normal tissues. LUAD patients with low expression levels of KLF15 have worse prognosis than those with high expression levels of KLF15. KLF15 could suppress cell growth, which was partly via up-regulating CDKN1 A/p21 and CDKN2A/p15. Our findings suggested that KLF15 showed a significant role in LAUD progression and may shed LIGHT on a promising novel therapeutic target for blocking progression of LAUD.

Keywords

CDKN1A/p21; CDKN2A/p15; KLF15; LUAD; Prognosis; Proliferation.

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