2. Academic Validation
  3. Acetylshikonin stimulates glucose uptake in L6 myotubes via a PLC-β3/PKCδ-dependent pathway

Acetylshikonin stimulates glucose uptake in L6 myotubes via a PLC-β3/PKCδ-dependent pathway

  • Biomed Pharmacother. 2019 Apr:112:108588. doi: 10.1016/j.biopha.2019.01.049.
Wendong Huang 1,  Jiacheng Zeng 2,  Zhaochun Liu 3,  Meiling Su 2,  Qisen Li 2,  Banghao Zhu 4
Affiliations

Affiliations

  • 1 Department of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China; Department of Pharmacy, Maoming People's Hospital, Maoming, China.
  • 2 Department of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
  • 3 Department of Pharmacy, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, China.
  • 4 Department of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China. Electronic address: zhubh@mail.sysu.edu.cn.
PMID: 30780104 DOI: 10.1016/j.biopha.2019.01.049
Abstract

Acetylshikonin, a naphthoquinone derivative derived from Lithospermum erythrorhizon, has been shown to have various pharmacological activities; however, its effect on diabetes has rarely been reported. We investigated the hypoglycemic effect of acetylshikonin and found that it decreased blood glucose to a greater extent than Insulin and improved glucose tolerance in mice. It also increased glucose uptake in L6 myotubes by inducing the expression and translocation of glucose transporter 4 via decomposition of phosphatidylinositol, increased generation of diacylglycerol, and activation of protein kinase C delta cascades; this is an insulin-, reactive oxygen species-, and AMP-activated protein kinase-independent pathway for glucose uptake. Our findings highlight the antidiabetic potential of acetylshikonin via a possible novel pathway for glucose uptake in L6 myotubes.

Keywords

Acetylshikonin; Diabetes; Glucose uptake; Phosphatidylinositol; Protein kinase C delta.

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