2. Academic Validation
  3. Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

  • Blood Adv. 2019 Mar 12;3(5):729-733. doi: 10.1182/bloodadvances.2018025429.
Guojie Wu 1 2,  Blake A Mazzitelli 1 2,  Adam J Quek 1 2,  Matthew J Veldman 1 2,  Paul J Conroy 1 2,  Tom T Caradoc-Davies 1 2 3,  Lisa M Ooms 1 2,  Kellie L Tuck 4,  Jonathan G Schoenecker 5,  James C Whisstock 1 2 6,  Ruby H P Law 1 2
Affiliations

Affiliations

  • 1 ARC Centre of Excellence in Advanced Molecular Imaging, and.
  • 2 Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
  • 3 Australian Synchrotron, Clayton, Australia.
  • 4 School of Chemistry, Monash University, Melbourne, Australia.
  • 5 Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN; and.
  • 6 South East University-Monash Joint Institute, Institute of Life Sciences, Southeast University, Nanjing, China.
PMID: 30814058 DOI: 10.1182/bloodadvances.2018025429
Abstract

  1. TXA is an active-site inhibitor of uPA.

  2. TXA attenuates MDA-MB-231 BAG cell migration and inhibits endogenous uPA activity.

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