1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. PAI-1

PAI-1

Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and functionally serves to suppress tissue and plasma fibrinolysis.

PAI-1 is a member of the serpin family of proteins and exists in multiple conformations of which a minor component, the “active” form, exhibits inhibitory effects against tPA and uPA.

PAI-1 is an endogenous inhibitor of urokinase-type plasminogen activator (uPA), and its expression is regulated by a number of intrinsic factors (e.g., cytokines and growth factors) and extrinsic factors (e.g., cellular stress).

PAI-1 seems to play a pivotal role in tumor growth and may represent a potential therapeutic target for bladder cancer.

PAI-1 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-16511
    Upamostat >98.0%
    Upamostat (WX-671) 是一种丝氨酸蛋白酶抑制剂。Upamostat 是具有口服活性的 WX-UK1 前药,是一种尿激酶型纤溶酶原激活剂 (uPA) 抑制剂。
  • HY-15253
    Tiplaxtinin Inhibitor 98.42%
    Tiplaxtinin 是一种有效的,具有口服活性的选择性的纤溶酶原激活物抑制剂-1 (PAI-1) 抑制剂,IC50 为 2.7 μM。
  • HY-101761
    TM5441 Inhibitor 98.18%
    TM5441 是一种口服生物可利用的纤溶酶原激活物抑制剂-1 抑制剂 (PAI-1),抑制多个癌症细胞系的IC50 值在 13.9 到 51.1 μM,并诱导几种人类癌症细胞的内在调亡。TM5441 减弱 Nω-硝基-1-精氨酸甲酯诱导的心脏高血压和血管衰老。
  • HY-100447
    TM5275 sodium Inhibitor 98.97%
    TM5275 sodium是纤溶酶原激活物抑制剂 (PAI-1),IC50值为6.95 μM。
  • HY-N1504
    Loureirin B Inhibitor 99.99%
    Loureirin B 是从剑叶龙血树中分离到的黄酮类化合物,为 PAI-1 的抑制剂,IC50 值为 26.10 μM;Loureirin B 同时可以抑制 KATP,以及 ERKJNK 的磷酸化,具有抗糖尿病的功效。
  • HY-101214
    UK-371804 Inhibitor >98.0%
    UK-371804是尿嘧啶型纤溶酶原激活物 (uPA) 的抑制剂,Ki值为10 nM。
  • HY-N0518
    Toddalolactone Inhibitor
    Toddalolactone,Toddalia asiatica 的主要成分,抑制重组人纤溶酶原激活物抑制物-1 (PAI-1) 的活性, IC50 为 37.31 μM。
  • HY-114330A
    ZK824859 hydrochloride Inhibitor
    ZK824859 hydrochloride 是一种口服有效的选择性尿激酶型纤溶酶原激活剂 (uPA) 抑制剂,用于人 uPA,tPA 和纤溶酶,IC50 分别为 79 nM,1580 nM 和 1330 nM。
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