1. Academic Validation
  2. Near-Infrared Light-Controllable Multifunction Mesoporous Polydopamine Nanocomposites for Promoting Infected Wound Healing

Near-Infrared Light-Controllable Multifunction Mesoporous Polydopamine Nanocomposites for Promoting Infected Wound Healing

  • ACS Appl Mater Interfaces. 2022 Jan 19;14(2):2534-2550. doi: 10.1021/acsami.1c19209.
Wei-Nan Zeng 1 Duan Wang 1 Qiu-Ping Yu 2 Ze-Ping Yu 1 Hao-Yang Wang 1 Cheng-Yu Wu 3 Si-Wei Du 3 Xing-Yu Chen 3 Jia-Fei Li 3 Zong-Ke Zhou 1 Yu Zeng 4 Yun Zhang 5
Affiliations

Affiliations

  • 1 Orthopedic Research Institution, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China.
  • 2 Health Management Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu 610041, China.
  • 3 West China Hospital/West China School of Medicine, Sichuan University, Chengdu 610041, China.
  • 4 Department of Hyperbaric Oxygen, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610041, China.
  • 5 Department of Traditional Chinese Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610041, China.
Abstract

The successful treatment of infected wounds requires strategies with effective antimicrobial, anti-inflammatory, and healing-promoting properties. Accordingly, the use of Cu2+ and Tetracycline (TC), which can promote angiogenesis, re-epithelialization, and collagen deposition, also Antibacterial activity, at the wound site, has shown application prospects in promoting infected wound repair. However, realizing controllable release to prolong action time and avoid potential toxicities is critical. Moreover, near-infrared LIGHT (NIR)-activated mesoporous polydopamine nanoparticles (MPDA NPs) reportedly exert anti-inflammatory effects by eliminating the Reactive Oxygen Species generated during inflammatory responses. In this study, we assess whether Cu2+ and TC loaded in MPDA NPs can accelerate infected wound healing in mice. In particular, Cu2+ is chelated and immobilized on the surface of MPDA NPs, while a thermosensitive phase-change material (PCM; melting point: 39-40 °C), combined with Antibiotics, was loaded into the MPDA NPs as a gatekeeper (PPMD@Cu/TC). Results show that PPMD@Cu/TC exhibits significant great photothermal properties with NIR irradiation, which induces the release of Cu2+, while inducing PCM melting and, subsequent, TC release. In combination with anti-inflammatory therapy, NIR-triggered Cu2+ and TC release enables the nanocomposite to eradicate Bacterial wound infections and accelerate healing. Importantly, negligible damage to primary organs and satisfactory biocompatibility were observed in the murine model. Collectively, these findings highlight the therapeutic potential of this MPDA-based platform for controlling Bacterial infection and accelerating wound healing.

Keywords

angiogenesis; antibacterial; infected wound healing; mesoporous polydopamine; multifunction nanocomposites.

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