2. Academic Validation
  3. Neutrophil extracellular traps promote invasion and metastasis via NLRP3-mediated oral squamous cell carcinoma pyroptosis inhibition

Neutrophil extracellular traps promote invasion and metastasis via NLRP3-mediated oral squamous cell carcinoma pyroptosis inhibition

  • Cell Death Discov. 2024 May 2;10(1):214. doi: 10.1038/s41420-024-01982-9.
Rundong Zhai # 1 2 3,  Zizhen Gong # 1 2 3,  Mengqi Wang # 1 2 3,  Zihui Ni 1 2 3,  Jiayi Zhang 1 2 3,  Mengyao Wang 1 2 3,  Yu Zhang 1 2 3,  Fanrui Zeng 1 2 3,  Ziyue Gu 4 5,  Xingyu Chen 1 2 3,  Xiudi Wang 1 2 3,  Pengcheng Zhou 1 2 3,  Laikui Liu 6 7 8,  Weiwen Zhu 9 10 11
Affiliations

Affiliations

  • 1 State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Jiangsu, China.
  • 2 Department of Basic Science of Stomatology, The Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu, China.
  • 3 Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Jiangsu, China.
  • 4 Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
  • 5 College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
  • 6 State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Jiangsu, China. my_yunkong@njmu.edu.cn.
  • 7 Department of Basic Science of Stomatology, The Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu, China. my_yunkong@njmu.edu.cn.
  • 8 Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Jiangsu, China. my_yunkong@njmu.edu.cn.
  • 9 State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Jiangsu, China. weiwenzhu@njmu.edu.cn.
  • 10 Department of Basic Science of Stomatology, The Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu, China. weiwenzhu@njmu.edu.cn.
  • 11 Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Jiangsu, China. weiwenzhu@njmu.edu.cn.
  • # Contributed equally.
PMID: 38697992 DOI: 10.1038/s41420-024-01982-9
Abstract

Neutrophil extracellular traps (NETs) are reticular structures composed of neutrophil Elastase (NE), Cathepsin G (CG) and DNA-histone Enzyme complexes. Accumulating evidence has revealed that NETs play important roles in tumor progression, metastasis, and thrombosis. However, our understanding of its clinical value and mechanism of action in oral squamous cell carcinoma (OSCC) is limited and has not yet been systematically described. Here, we aimed to investigate the clinical significance of NETs in OSCC and the mechanisms by which they affect its invasive and metastatic capacity. Our results demonstrated that high enrichment of NETs is associated with poor prognosis in OSCC, and mechanistic studies have shown that NE in NETs promotes invasion and metastasis via NLRP3-mediated inhibition of Pyroptosis in OSCC. These findings may provide a new therapeutic approach for OSCC.

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